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프라바스타틴에서 SLCO1B1*15의 약동학적 영향 : 체계적 고찰 및 메타분석
Effect of SLCO1B1*15 on Pravastatin Pharmacokinetics : A Systematic Review and Meta-analysis
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- 발행기관
- 한국임상약학회 바로가기
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- 간행물
- 한국임상약학회지 KCI 등재 바로가기
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- 통권
- 제24권 제4호 (2014.12)바로가기
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- 페이지
- pp.231-239
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- 저자
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- 언어
- 영어(ENG)
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- URL
- https://www.earticle.net/Article/A238900
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원문정보
초록
- 영어
- Background and objective: Pravastatin has been shown to have favorable risk-benefit profile when it is administered to hypercholesterolemic subjects to prevent cardiovascular events. However, subjects with impaired OATP1B1 activity may be more susceptible to pravastatin-induced muscle toxicity than subjects with normal OATP1B1 activity. A systematic review was conducted to evaluate the effect of SLCO1B1 genetic polymorphism on pharmacokinetics of pravastatin. Method: Medline® and Embase® were searched for relevant studies until July 2013. The search terms used were pravastatin AND (SLCO1B1 OR OATP1B1 OR LST1 OR SLC21A6) AND (gene OR genetic* OR genomic* OR pharmacogenet* OR pharmacogenom* OR polymorph*). Results: A metaanalysis of the area under the concentration-time curve (AUC) of pravastatin in SLCO1B1*15 and SLCO1B1*1a/ *1a was conducted. Five studies met all the inclusion criteria and methodological requirements. There was no statistically significant difference in the AUC value between SLCO1B1*15 and SLCO1B1*1a/*1a (p=0.728). However, SLCO1B1*15 participants exhibited significantly higher AUC values than SLCO1B1*1b/*1b carriers (p<0.001). In case of SLCO1B1*15*15 carriers, they had significantly higher AUC value than SLCO1B1*1a/*1a subjects (p=0.002). Lastly, compared with to the subjects of SLCO1B1*1a/*1a, the carriers of heterozygous SLCO1B1*15 increased the AUC value of pravastatin statistically significantly in Asian population (p=0.014). Conclusion: The present meta-analysis suggests that subjects with SLCO1B1*15 are associated with increased AUC of pravastatin.
목차
Abstract
METHODS
Search Strategy
Study Inclusion Criteria
Exclusion Criteria
Data Extraction and Quality Assessment
Statistical Analyses
RESULTS
Included Studies
Meta-analysis
Sensitivity Analysis and Publication Bias
DISCUSSION
CONCLUSION
REFERENCES
키워드
OATP1B1 OATP2 OATP-C SLCO1B1 pravastatin pharmacokinetics저자
간행물 정보
발행기관
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- 발행기관명
- 한국임상약학회 [Korean College of Clinical Pharmacy]
- 설립연도
- 1
- 분야
- 의약학>약학
- 소개
- 합리적 약물치료(rational pharmacotherapy)의 보장 및 증진을 궁극목적으로 하며 이를 달성하기 위해 임상약학의 발전과 회원 상호간의 친목을 도모한다.
간행물
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- 간행물명
- 한국임상약학회지 [Korean Journal of Clinical Pharmacy]
- 간기
- 계간
- pISSN
- 1226-6051
- 수록기간
- 1991~2026
- 등재여부
- KCI 등재
- 십진분류
- KDC 518 DDC 615
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