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The Bathing Effect of Hydrogen Reduced Water on UVB Skin-Mediated Injury in Hairless Mice

첫 페이지 보기
  • 발행기관
    한국물학회 바로가기
  • 간행물
    한국물학회 학술대회 바로가기
  • 통권
    2013 International Healthy Drinking Water Symposium (2013.03)바로가기
  • 페이지
    pp.184-184
  • 저자
    Ma Easter Joy Sajo, Rosa Mistica Ignacio, Yang-Suk Yoon, Cheol-Su Kim, Dong-Heui Kim, Soo-Ki Kim, Kyu-Jae Lee
  • 언어
    한국어(KOR)
  • URL
    https://www.earticle.net/Article/A234183

원문정보

초록

영어
Exposure to UVB radiation induced skin damage that results to increase risk of skin cancer. Despite the clinical importance of skin-induced damage, antioxidants imposed limited therapeutic success. Hydrogen molecule (H2) has been known as a safe antioxidant in the prevention and therapeutic approach towards several diseases. Drinking hydrogen reduced water, inhalation of hydrogen gas, and injecting H2-dissolved saline are widely accepted to incorporate H2 in the body. However, there is no document about the beneficial effect of taking a hydrogen bath. Here, we investigated the effect of hydrogen bathing on the UVBinduced skin damage in hairless mice. For this, mice of the bathing group are allowed to freely swim on HRW, and let the HRW penetrate for 60 mins. Scoring of skin injury, ROS enzyme activity quantification, cytokine analysis, and ultrastructural change of corneocytes were measured after exposure to an UVB radiation of 360-540 mJ/cm2. In summary, the bathing with HRW significantly reduces the levels of skin damaged, as well as increased activity of glutathione peroxidase. Further, the effect of HRW on cytokine network in the skin after UVB exposure revealed that HRW significantly decreased the level of inflammatory cytokines such as IL-1β, IL-6,TNF-α and IFN-y. Finally, scanning electron microscopy data revealed low number of defected corneocytes and ultrastructural changes, suggesting that HRW bathing protected against UV-induced cell damage.

키워드

Antioxidant Hydrogen water Bathing Hairless mouse

저자

  • Ma Easter Joy Sajo [ Department of Environmental Medical Biology and Institute for Poverty Alleviation and International Development, Yonsei University, Korea ]
  • Rosa Mistica Ignacio [ Department of Environmental Medical Biology ]
  • Yang-Suk Yoon [ Department of Environmental Medical Biology ]
  • Cheol-Su Kim [ Department of Microbiology, Wonju College of Medicine, Yonsei University ]
  • Dong-Heui Kim [ Department of Environmental Medical Biology ]
  • Soo-Ki Kim [ Department of Microbiology, Wonju College of Medicine, Yonsei University ]
  • Kyu-Jae Lee [ Department of Environmental Medical Biology and Institute for Poverty Alleviation and International Development, Yonsei University, Korea ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국물학회 [The Korean Water Society]
  • 설립연도
    2010
  • 분야
    자연과학>생물학
  • 소개
    기능수관련연구 경영과 정보를 공유, 일본 중국기능수재단 협회전문가 초빙하여 학회와의 정보교류 기능수관련 학회 및 학술지를 발행하여 물관련연구정보교류에 목적을 두고 있음.

간행물

  • 간행물명
    한국물학회 학술대회
  • 간기
    부정기
  • 수록기간
    2013~2024
  • 십진분류
    KDC 539 DDC 628

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