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만성신부전 환자의 혈관 석회화와 사망률에 미치는 인결합제의 영향
Effect of Phosphate Binders on Vascular Calcification and Mortality in Korean Patients with Chronic Kidney Disease

첫 페이지 보기
  • 발행기관
    한국임상약학회 바로가기
  • 간행물
    한국임상약학회지 KCI 등재 바로가기
  • 통권
    제24권 제3호 (2014.09)바로가기
  • 페이지
    pp.199-205
  • 저자
    신혜연
  • 언어
    한국어(KOR)
  • URL
    https://www.earticle.net/Article/A232229

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원문정보

초록

영어
Objectives: Current studies are debating on the association of vascular calcification and the benefit of treatment to lower serum phosphorus level in patients with chronic kidney disease. The aim of this study was to evaluate the association of mortality and risk of vascular calcification in patients with CKD who were taking phosphate binders. Methods: This study was conducted through retrospective medical chart review for 420 patients aged 18 years and older who were admitted for chronic kidney disease. Results: Vascular calcification was not statistically significantly associated with increased mortality in patients with CKD [16.7% vs. 19.2%; 95% CI; 0.388 to 1.818 (p=0.656)]. Intervention of calcium-based phosphate binders was not significantly associated with vascular calcification in patients with CKD [9.1% vs. 12.5%; 95% CI; 0.364 to 1.358 (p=0.292)]. Ca x P product ≥ 55 mg2/dL2 was not significantly associated with increased 1 year mortality in patients with CKD [25.4% vs. 17.5%; 95% CI; 0.851 to 3.013 (p=0.142)]. Intervention of sevelamer was significantly associated with reduced 1 year mortality in patients with CKD than that of patients who did not take sevelamer [6.3% vs. 25.3%; 95% CI; 0.044 to 0.880 (p=0.020)]. Conclusion: There was not a statistically significant association between vascular calcification and phosphate binder’s use. But phosphate binder use was significantly associated with decreased mortality in patients with CKD.

목차

Abstract
 연구 방법
  연구대상
  질병의 정의 및 자료 수집
  신부전의 기준 및 전해질의 기준
  분석방법
 연구 결과
  환자의 기본 특성
  인결합제 사용과 사망률
  인결합제 사용과 혈관의 석회화
 고찰
 결론
 감사의 말씀
 참고문헌

키워드

chronic kidney disease vascular calcification mortality phosphate binders

저자

  • 신혜연 [ Hye Yeon Sin | 덕성여자대학교 약학대학 ] Correspondence to

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국임상약학회 [Korean College of Clinical Pharmacy]
  • 설립연도
    1
  • 분야
    의약학>약학
  • 소개
    합리적 약물치료(rational pharmacotherapy)의 보장 및 증진을 궁극목적으로 하며 이를 달성하기 위해 임상약학의 발전과 회원 상호간의 친목을 도모한다.

간행물

  • 간행물명
    한국임상약학회지 [Korean Journal of Clinical Pharmacy]
  • 간기
    계간
  • pISSN
    1226-6051
  • 수록기간
    1991~2026
  • 등재여부
    KCI 등재
  • 십진분류
    KDC 518 DDC 615

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