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제2형 당뇨병 환자에서 시타글립틴과 메트포민 고정 복합제 투여와 단일제 병용간의 복약 순응도, 효과 및 약가에 대한 비교 연구
Comparisons of Adherence, Efficacy and Price between Sitagliptin/Metformin Fixed-dose Combination Tablets and Concomitant Administration of Sitagliptin and Metformin in Type 2 Diabetes Mellitus Patients
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- 발행기관
- 한국임상약학회 바로가기
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- 간행물
- 한국임상약학회지 KCI 등재 바로가기
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- 통권
- 제24권 제3호 (2014.09)바로가기
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- 페이지
- pp.193-198
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- 저자
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- 언어
- 한국어(KOR)
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- URL
- https://www.earticle.net/Article/A232228
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4,000원
원문정보
초록
- 영어
- Objective: This study was conducted to compare the adherence, clinical and economical utility of fixed- dose combination tablets of sitagliptin/metformin with concomitant administration of sitagliptin and metformin in patients with type 2 diabetes mellitus. Methods: Adherence was measured as the medication possession ratio (MPR) of ≥ 80%, and MPR was calculated as the number of total prescription days divided by the total treatment period. Hemoglobin A1C (HbA1c) differences between baseline and predetermined periods were analyzed. Proportions of patients who achieved HbA1c less than 6.5% for three or more consecutive times were compared. To evaluate cost-effectiveness, prices of sitagliptin, metformin and sitagliptin/metformin tablets were investigated. Results: More than 90% of patients showed adherence in both groups (92.0% in fixed-dose combination group vs 95.9% in concomitant administration group), and there was no statistically significant difference (P = 0.113). Proportion of patients with HbA1c less than 6.5% for three or more consecutive times tended to be somewhat higher in fixed dose combination group than in concomitant administration group without a statistically significant difference (32.6% vs. 28.0%, P = 0.344). Total price of metformin and sitagliptin was cheaper up to 222 KRW in the case of fixed-dose combination tablets compared to the case of concomitant administration. Conclusion: The sitagliptin/metformin fixed-dose combination tablet had a similar patient adherence and was not significantly different in efficacy to the concomitant administration of each component. In terms of drug prices, fixeddose combination tablets were cheaper than concomitant administration of each tablet.
목차
Abstract
연구 방법
대상환자 및 자료수집
자료분석
통계분석
연구 결과
대상환자의 특성
복약 순응도
혈중 HbA1c 수치 비교
약가 비교
고찰 및 결론
참고문헌
키워드
sitagliptin metformin fixed-dose combination concomitant administration adherence efficacy price저자
간행물 정보
발행기관
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- 발행기관명
- 한국임상약학회 [Korean College of Clinical Pharmacy]
- 설립연도
- 1
- 분야
- 의약학>약학
- 소개
- 합리적 약물치료(rational pharmacotherapy)의 보장 및 증진을 궁극목적으로 하며 이를 달성하기 위해 임상약학의 발전과 회원 상호간의 친목을 도모한다.
간행물
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- 간행물명
- 한국임상약학회지 [Korean Journal of Clinical Pharmacy]
- 간기
- 계간
- pISSN
- 1226-6051
- 수록기간
- 1991~2026
- 등재여부
- KCI 등재
- 십진분류
- KDC 518 DDC 615
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