Earticle

초록

영어

Oral exposure of humans by excess amounts of arsenic may cause disturbances of the reproductive system. In the present study, such exposure was modelled in rats, with the support of sperm principal parameters and histopathological observations. Male Sprague–Dawley rats were randomly divided into three groups where the group I was served as a normal control, group II was received sodium meta-arsenite as arsenic (10 mg/kg b.w/day) and a combination of sodium meta- arsenite and sodium selenite (3 mg/kg b.w/day) in group III. After 6 weeks, there was no significant change in testis weight and in total motility of all the three experimental groups, whereas, rapid moving spermatozoa, moderately moving spermatozoa and slow moving spermatozoa were significantly decreased in arsenic treated rats as compared to control rats. The other sperm principal parameters like progressiveness, average path velocity, straightness linear velocity (VSL), curvilinear velocity (VCL), straightness, linearity sperm head elongation ratio, area, linearity amplitude of lateral head department (ALH) and beat cross frequency (BCF) were found to be reduced in arsenic intoxicated rats. These results are not correlated with the histological studies. On oral administration of selenium ameliorated the adverse effects of arsenic as compared to arsenic alone treated rats. Our findings clearly demonstrate that administration of selenium could prevent some of the deleterious effects of arsenic in the testis.

목차

ABSTRACT
 INTRODUCTION
 MATERIALS AND METHODS
  Chemicals and Reagents
  Animals
  Preparation and Administration of Arsenic and Selenium
  Experimental Time Line
  Measurement of Sperm Motility, Velocity, Movements and Morphology
  Histopathological Examination of Testis
  Statistical Analysis
 RESULTS
  Effect of Selenium and Arsenic on Testis Weight and Sperm Motility
  Effect of Selenium and Arsenic on Detailed Motion Characteristics
  Changes in Motion and Morphological Index
  Effect of Selenium and Arsenic on ALH and BCF
  Effect of Selenium and Arsenic on Histopathological Studies
 DISCUSSION
 CONCLUSION
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Abdulkadhar Mohamed Jalaludeen [ Department of Animal Science, College of Natural Science, Konkuk University, Chungju 380-701, Korea. ]
• Ran Lee [ Department of Animal Science, College of Natural Science, Konkuk University, Chungju 380-701, Korea ]
• Won Young Lee [ Department of Animal Science, College of Natural Science, Konkuk University, Chungju 380-701, Korea ]
• Dong Hoon Kim [ Animal Biotechnology Division, National Institute of Animal Science, RDA, Suwon 441-706, Korea ]
• Hyuk Song [ Department of Animal Science, College of Natural Science, Konkuk University, Chungju 380-701, Korea. ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  Reproductive & developmental biology

• 간기

  계간

• pISSN

  1738-2432

• eISSN

  2288-0151

• 수록기간

  1977~2018

• 십진분류

  KDC 527 DDC 636