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A Comparison of Optimal Biomarker Combinations for Benign-Cancer and Normal-Cancer Distinguishment in Ovarian Cancer Screening

첫 페이지 보기
  • 발행기관
    보안공학연구지원센터(IJBSBT) 바로가기
  • 간행물
    International Journal of Bio-Science and Bio-Technology SCOPUS 바로가기
  • 통권
    Vol.6 No.2 (2014.04)바로가기
  • 페이지
    pp.43-50
  • 저자
    Hye-Jeong Song, Jong-Ki Lim, Ji-Eun Chang, Chan-Young Park, Jong-Dae Kim, Yu-Seop Kim
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A229883

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원문정보

초록

영어
This paper compares the performance of the combination of biomarkers to distinguish benign tumor from cancer and normal from cancer, from 21 urine biomarkers. Samples consist of 79 healthy women, 119 patients with benign tumor, and 137 patients with ovarian cancer. The concentrations of the 21 biomarkers were extracted using Luminex-PRA. The area under the curve (AUC) of ROC was evaluated to determine the optimum marker combination showing the best performance. The performance of the selected combination was confirmed with logistic regression. The highest AUC value of distinguishing benign tumor from cancer with a combination of two biomarkers and three biomarkers are 87.97% and 91.38%, respectively. And the highest AUC value of distinguishing normal from cancer with a combination of two biomarkers and three biomarkers are 87.39% and 90.68%, respectively. Interestingly, the benign-cancer classification shows a little higher performance than the normal-cancer classification.

목차

Abstract
 1. Introduction
 2. Data Collection
 3. Methods
 4. Results
 5. Conclusion
 Acknowledgements
 References

키워드

Ovarian Cancer Benign-Cancer Normal-Cancer Biomarker Combination

저자

  • Hye-Jeong Song [ Dept. of Ubiquitous Computing, Hallym University, Bio-IT Research Center, Hallym University, 1 Hallymdaehak-gil, Chuncheon, Gangwon-do, 200-702, Korea ]
  • Jong-Ki Lim [ Dept. of Ubiquitous Game Engineering, Hallym University, Bio-IT Research Center, Hallym University, 1 Hallymdaehak-gil, Chuncheon, Gangwon-do, 200-702, Korea ]
  • Ji-Eun Chang [ Dept. of Ubiquitous Computing, Hallym University, Bio-IT Research Center, Hallym University, 1 Hallymdaehak-gil, Chuncheon, Gangwon-do, 200-702, Korea ]
  • Chan-Young Park [ Dept. of Ubiquitous Computing, Hallym University, Bio-IT Research Center, Hallym University, 1 Hallymdaehak-gil, Chuncheon, Gangwon-do, 200-702, Korea ]
  • Jong-Dae Kim [ Dept. of Ubiquitous Computing, Hallym University, Bio-IT Research Center, Hallym University, 1 Hallymdaehak-gil, Chuncheon, Gangwon-do, 200-702, Korea ]
  • Yu-Seop Kim [ Dept. of Ubiquitous Computing, Hallym University, Bio-IT Research Center, Hallym University, 1 Hallymdaehak-gil, Chuncheon, Gangwon-do, 200-702, Korea ] Corresponding author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    보안공학연구지원센터(IJBSBT) [Science & Engineering Research Support Center, Republic of Korea(IJBSBT)]
  • 설립연도
    2006
  • 분야
    공학>컴퓨터학
  • 소개
    1. 보안공학에 대한 각종 조사 및 연구 2. 보안공학에 대한 응용기술 연구 및 발표 3. 보안공학에 관한 각종 학술 발표회 및 전시회 개최 4. 보안공학 기술의 상호 협조 및 정보교환 5. 보안공학에 관한 표준화 사업 및 규격의 제정 6. 보안공학에 관한 산학연 협동의 증진 7. 국제적 학술 교류 및 기술 협력 8. 보안공학에 관한 논문지 발간 9. 기타 본 회 목적 달성에 필요한 사업

간행물

  • 간행물명
    International Journal of Bio-Science and Bio-Technology
  • 간기
    격월간
  • pISSN
    2233-7849
  • 수록기간
    2009~2016
  • 등재여부
    SCOPUS
  • 십진분류
    KDC 505 DDC 605

이 권호 내 다른 논문 / International Journal of Bio-Science and Bio-Technology Vol.6 No.2

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