Earticle

초록

영어

During pregnancy, diabetes mellitus exerts detrimental effects on the development of the fetus, especially the central nervous system. In the current study, we evaluated the effects of postnatal treadmill exercise on short-term memory in relation with cell proliferation and apoptosis in the hippocampus of rat pups born to streptozotocin (STZ)-induced dia-betic maternal rats. Adult female rats were mated with male rats for 24 h. Two weeks after mating, the pregnant female rats were divided into two groups: control group and STZ injection group. The pregnant rats in the STZ injection group were administered 40 mg/kg of STZ intraperito-neally. After birth, the rat pups were divided into the following four groups: control group, control with postnatal exercise group, maternal STZ-in-jection group, and maternal STZ-injection with postnatal exercise group. The rat pups in the postnatal exercise groups were made to run on a treadmill for 30 min once a day, 5 times per week for 2 weeks beginning 4 weeks after birth. The rat pups born to diabetic rats were shown to have short-term memory impairment with suppressed cell proliferation and increased apoptosis in the hippocampal dentate gyrus. Postnatal treadmill exercise alleviated short-term memory impairment by increased cell proliferation and suppressed apoptosis in the rat pups born to dia-betic rats. These findings indicate that postnatal treadmill exercise may be used as a valuable strategy to ameliorate neurodevelopmental prob-lems in children born to diabetics.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Animals and treatments
  Exercise protocols
  Determination of short-term memory
  Tissue preparation
  BrdU immunohistochemistry
  Caspase-3 immunohistochemistry
  Bax immunohistochemistry
  TUNEL staining
  Data analysis
 RESULTS
  Effect of postnatal treadmill exercise on memory in the step-down avoidance task
  Effect of postnatal treadmill exercise on the number of BrdU-positive cells in the hippocampal dentate gyrus
  Effect of postnatal treadmill exercise on the number of caspase-3-positive cells in the hippocampal dentate gyrus
  Effect of postnatal treadmill exercise on the number of Bax-positive cells in the hippocampal dentate gyrus
  Effect of postnatal treadmill exercise on the number of TUNEL-positive cells in the hippocampal dentate gyrus
 DISCUSSION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Young Hoon Kim [ Department of Urology, Gachon University Gil Medical Center, Gachon University School of Medicine, Incheon, Korea ]
• Yun-Hee Sung [ Department of Physical Therapy, College of Natural Science, Kyungnam University, Changwon, Korea ]
• Hee-Hyuk Lee [ Department of Sports Science, College of Life Science and Nano Technology, Hannam University, Daejeon, Korea ]
• Il-Gyu Ko [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Sung-Eun Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Mal-Soon Shin [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Bo-Kyun Kim [ KBS Institute of the Sports, Arts and Science, Seoul, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613