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Estrogen Regulates the Expression of Aminoacyl-tRNA-Synthetase-Interacting Multifunctional Protein-1 (Aimp1) in the Mouse Uterus

첫 페이지 보기
  • 발행기관
    한국동물생명공학회(구 한국동물번식학회) 바로가기
  • 간행물
    한국동물번식학회 한중일 심포지엄 바로가기
  • 통권
    The 3rd Korea-China-Japan Joint Symposium on Animal Reproduction (2014.06)바로가기
  • 페이지
    pp.47-47
  • 저자
    Miseon Park, Eun Jin Lim, Si-jeong Bea, Eunhye Kim, Young-eun Lee, Dong Ryul Lee, Youngsok Choi
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A227667

원문정보

초록

영어
Aimp1 is known as a multifunctional cytokine in various cellular events. Recent study showed Aimp1 is localized in glandular epithelial, endothelial, and stromal cells in functionalis and basalis layers of the endometrium. However, the regulatory mechanism of Aimp1 in the uterus remains unknown. In the present study, we found that Aimp1 is expressed in the mouse uterus. Aimp1 transcripts were decreased at diestrus stage. However, the level of Aimp1 protein was significantly increased in the luminal epithelium in the uterine endometrium at the estrus stage during the estrous cycle. In addition, we found that the treatment of estrogen increased the expression of Aimp1 in the uterus. The treatment of estrogen increased Aimp1 expression in the uterus of ovarectomized mice. We identified one estrogen receptor binding element (ERE) on the mouse Aimp1 promoter. The activity of Aimp1 promoter was increased with estrogen treatment. Our findings indicate that Aimp1 might act as an important regulator to remodel the uterine endometrium and its expression might be regulated by estrogen during the estrous cycle. This will give us better understanding the dynamic change of uterine remodeling during the estrous cycle.

저자

  • Miseon Park [ Department of Biomedical Science, College of Medicine CHA University, Fertility Center of CHA Gangnam Medical Center ]
  • Eun Jin Lim [ Department of Biomedical Science, College of Medicine CHA University ]
  • Si-jeong Bea [ Department of Biomedical Science, College of Medicine CHA University ]
  • Eunhye Kim [ Department of Biomedical Science, College of Medicine CHA University ]
  • Young-eun Lee [ Department of Biomedical Science, College of Medicine CHA University ]
  • Dong Ryul Lee [ Department of Biomedical Science, College of Medicine CHA University, Fertility Center of CHA Gangnam Medical Center ]
  • Youngsok Choi [ Department of Biomedical Science, College of Medicine CHA University, Fertility Center of CHA Gangnam Medical Center ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국동물생명공학회(구 한국동물번식학회) [The Korean Society of Animal Reproduction and Biotechnology]
  • 설립연도
    1976
  • 분야
    농수해양>축산학
  • 소개
    동물번식생리학, 동물생명공학, 수의학, 인공수정 및 수정란이식을 이용한 동물개량에 관한 이론과 기술의 발전을 통해 학계, 연구계, 산업계 및 양축가 상호간의 협력을 도모함으로써 동물과학발전 및 사회일반의 이익에 기여 한다는 목적을 위해 노력해 나가겠습니다.

간행물

  • 간행물명
    한국동물번식학회 한중일 심포지엄
  • 간기
    연간
  • 수록기간
    2014~2014
  • 십진분류
    KDC 527 DDC 636

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