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Actin-capping Protein Play Essential Roles in Spindle Migration and Polar Body Protrusion In Maturing Mouse Oocytes

첫 페이지 보기
  • 발행기관
    한국동물생명공학회(구 한국동물번식학회) 바로가기
  • 간행물
    Reproductive & Developmental Biology(Supplement) 바로가기
  • 통권
    Volume 38 No 2 Supplement (2014.06)바로가기
  • 페이지
    pp.14-14
  • 저자
    Yu-jin Jo, Chang-Eun Park, Suk Namgoong, Nam-Hyung Kim
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A227090

원문정보

초록

영어
Actin polymerization is essential for various stages of mammalian oocyte maturation, including asymmetric spindle migration, cortical actin cap formation, polar body extrusion, and cytokinesis. The heterodimeric actin capping protein (CP) is an essential element of the actin cytoskeleton. It binds to the fast-growing (barbed) ends of actin filaments, thereby blocking their elongation, and plays essential roles in various actin-mediated cellular processes. However, the roles of CP in mammalian oocyte maturation are poorly understood. We investigated the roles of CP in mouse oocytes, and found that CP is essential for correct asymmetric spindle migration and polar body extrusion. CP colocalized with cortical actin in immature oocytes, but its localization changed during maturation. Experiments in which CP was knocked down or ectopically overexpressed revealed that this protein is critical for Perturbations in the level of CP impaired spindle migration and polar body extrusion during oocyte maturation. Taken together, this study shows that CP is an essential component of the actin cytoskeleton machinery that plays crucial roles in oocyte maturation.

키워드

Oocyte maturation Actin Spindle Migration Mouse oocyte

저자

  • Yu-jin Jo [ Department of Animal Sciences, Chungbuk National University ]
  • Chang-Eun Park [ Departmet of Biomedical Laboratory Science, Namseoul University ]
  • Suk Namgoong [ Department of Animal Sciences, Chungbuk National University ]
  • Nam-Hyung Kim [ Department of Animal Sciences, Chungbuk National University ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국동물생명공학회(구 한국동물번식학회) [The Korean Society of Animal Reproduction and Biotechnology]
  • 설립연도
    1976
  • 분야
    농수해양>축산학
  • 소개
    동물번식생리학, 동물생명공학, 수의학, 인공수정 및 수정란이식을 이용한 동물개량에 관한 이론과 기술의 발전을 통해 학계, 연구계, 산업계 및 양축가 상호간의 협력을 도모함으로써 동물과학발전 및 사회일반의 이익에 기여 한다는 목적을 위해 노력해 나가겠습니다.

간행물

  • 간행물명
    Reproductive & Developmental Biology(Supplement)
  • 간기
    연간
  • 수록기간
    2001~2017
  • 십진분류
    KDC 527 DDC 636

이 권호 내 다른 논문 / Reproductive & Developmental Biology(Supplement) Volume 38 No 2 Supplement

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