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Clopidogrel에 Proton Pump Inhibitors 병용 시 급성 관동맥 증후군 환자의 심장관련 부작용에 미치는 영향
Influence of the Concomitant Use of Clopidogrel and Proton Pump Inhibitors on Adverse Cardiovascular Events in Korean Patients with Acute Coronary Syndrome

첫 페이지 보기
  • 발행기관
    한국임상약학회 바로가기
  • 간행물
    한국임상약학회지 KCI 등재 바로가기
  • 통권
    제24권 제2호 (2014.06)바로가기
  • 페이지
    pp.106-114
  • 저자
    김수현, 이유정
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A223049

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원문정보

초록

영어
Purpose: Recent investigations suggest that the antiplatelet effect of clopidogrel may be decreased when this medication is taken together with certain proton pump inhibitors (PPIs). However, there has been no study conducted in Korea regarding the clinical effect of clopidogrel-PPI interaction. This study targeted patients who received stents to investigate the effect of the concomitant use of clopidogrel and PPIs on the occurrence of adverse cardiovascular events in Korean patients. Methods: The patients who received a stent insertion at the Yeouido St. Mary’s Hospital between January 2010 and April 2011 were included. The patients were divided into two groups, clopidogrel and clopidogrel + PPI, and followed for 12 months after the date of stent insertion using prescription history and medical records. The recurrence rates of the cardiovascular events among the two patient groups were statistically analyzed. Results: There was no difference between the two groups in the basic characteristics of the 157 patients in the clopidogrel group and the 62 patients in the clopidogrel + PPI group. Simple logistic regression showed a significantly higher rate of re-hospitalization in the clopidogrel + PPI group (OR=1.893, 95% CI 1.040-3.445, p=0.037). However, the results of the multivariate logistic regression of the variables found to have statistical significance by crosstabulation showed no significant difference in the rate of adverse cardiovascular events or re-hospitalization between the two groups. Conclusions: There was no significant difference between the clopidogrel and clopidogrel+PPI group among new patients with cardiovascular stents with respect to the occurrence of revascularization procedures, stent thrombosis, or chest pain, or with respect to the re-hospitalization rate for all cardiovascular events.

목차

Abstract
 METHODS
  Study subjects
  Data Collection and Method
  Statistical Analysis
 RESULTS
  Characteristics of the Subjects
  Analysis of Factors Affecting the Occurrence of Each Cardiovascular Event
  Univariate Logistic Regression Analysis between the Clopidogrel-only Group and the Clopidogrel + PPI group
  Multivariate Logistic Regression Analysis between the Clopidogrel-only Group and the Clopidogrel + PPI Group
  Adverse Cardiac Event Occurrence of Each PPI Medication in the Clopidogrel + PPI Group
 DISCUSSION
 REFERENCES

키워드

clopidogrel proton pump inhibitors interaction adverse cardiovascular events acute coronary syndrome

저자

  • 김수현 [ Su Hyun Kim | 여의도성모병원 약제팀 ]
  • 이유정 [ Yu Jeung Lee | 강원대학교 약학대학 ] Correspondence to

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국임상약학회 [Korean College of Clinical Pharmacy]
  • 설립연도
    1
  • 분야
    의약학>약학
  • 소개
    합리적 약물치료(rational pharmacotherapy)의 보장 및 증진을 궁극목적으로 하며 이를 달성하기 위해 임상약학의 발전과 회원 상호간의 친목을 도모한다.

간행물

  • 간행물명
    한국임상약학회지 [Korean Journal of Clinical Pharmacy]
  • 간기
    계간
  • pISSN
    1226-6051
  • 수록기간
    1991~2026
  • 등재여부
    KCI 등재
  • 십진분류
    KDC 518 DDC 615

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