Earticle

초록

영어

Attention-deficit hyperactivity disorder (ADHD) is a common neurobe-havioral disorder, and its symptoms are hyperactivity and deficits in learning and memory. Physical exercise increases dopamine synthesis and neuronal activity in various brain regions. In the present study, we investigate the duration-dependence of the treadmill exercise on hyper-activity in relation with dopamine expression in ADHD. Spontaneously hypertensive rats were used for the ADHD rats and Wistar-Kyoto rats were used for the control rats. The rats in the exercise groups were forced to run on a treadmill for 10 min, 30 min, and 60 min once daily for 28 consecutive days. For this experiment, open field test and immuno-histochemistry for tyrosine hydroxylase were conducted. The present results revealed that ADHD rats showed hyperactivity, and tyrosine hy-droxylase expression in the striatum and substantia nigra were de-creased in ADHD rats. Treadmill exercise alleviated hyperactivity and also increased TH expression in ADHD rats. Treadmill exercise for 30 min per day showed most potent suppressing effect on hyperactivity, and this dose of treadmill exercise also most potently inhibited tyrosine hydroxylase expression. The present study suggests that treadmill exer-cise for 30 min once a day is the most effective therapeutic intervention for ADHD patients.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Experimental animals
  Treadmill exercise protocol
  Open field test
  Tissue preparation
  TH immunohistochemistry
  Data analysis
 RESULTS
  Effect of treadmill exercise on hyperactivity in the open field test
  Effect of treadmill exercise on TH-immunoreactive fibers in the striatum
  Effect of treadmill exercise on TH expression in the SN
 DISCUSSION
 CONFLICT OF INEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Eun-Sang Ji [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Chang-Ju Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Jun Heon Park [ Kohwang Medical Research Institute, College of Medicine, Kyung Hee University, Department of Psychiatry, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Geon Ho Bahn [ Department of Psychiatry, College of Medicine, Kyung Hee University, Seoul, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613