Earticle

초록

영어

Adiponectin secreted from adipose tissue binds to two distinct adi-ponectin receptors (AdipoR1 and AdipoR2) identified and exerts its an-ti-diabetic effects in insulin-sensitive organs including liver, skeletal muscle and adipose tissue as well as amelioration of vascular dysfunc-tion in the various vasculatures. A number of experimental and clinical observations have demonstrated that circulating levels of adiponectin are markedly reduced in obesity, type 2 diabetes, hypertension, and coronary artery disease. Therapeutic interventions which can improve the action of adiponectin including elevation of circulating adiponectin concentration or up-regulation and/or activation of its receptors, could provide better understanding of strategies to ameliorate metabolic dis-orders and vascular disease. The focus of the present review is to sum-marize accumulating evidence showing the role of interventions such as pharmacological agents, exercise, and calorie restriction in the ex-pression of adiponectin and adiponectin receptors.

목차

Abstract
 INTRODUCTION
 EFFECTS OF INTERVENTIONS ON ADIPONECTIN AND ADIPONECTIN RECEPTORS
  Pharmacological and dietary intervention
  Exercise
  Calorie restriction, weight loss, and gastric bypass surgery
 CONCLUSIONS
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Sewon Lee [ Dalton Cardiovascular Research Center, University of Missouri-Columbia, MO, USA ]
• Hyo-Bum Kwak [ Department of Kinesiology, Inha University, Incheon, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613