Ga-Heon Jin, Min Woong Lee, Kyung Hoan Im, Tae Soo Lee
언어
영어(ENG)
URL
https://www.earticle.net/Article/A216672
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초록
영어
This study was initiated to investigate antioxidant, anti-acetylcholinesterase, and xanthine oxidase inhibitory activities and properties of fruiting bodies, mycelia, and fermentation culture filtrates from Phellinus igniarius. The contents of total phenols and flavonoid of fruit bodies, mycelia, and culture filtrate were 15.35-1.36 mg/g, 10.35-7.85 mg/g, and 8.25-5.36 mg/g. The 1,1- diphenyl-1-picrylhydrazyl (DPPH) radical scavenging abilities of the extracts from the fruiting bodies, mycelia, and culture filtrates were 90.25-95.60%, 78.82-85.24%, and 76.32-82.50% at 50-400 μg/mL, respectively. The chelating ability of fruiting body extract on ferrous ions was higher than those of mycelia and culture filtrates tested. The anti-acetylcholinesterase inhibitory activity of the fruiting body extract at 400 μg/mg exhibited 91.10% on AChE, which is lower than that of positive control, galanthamine (94.82%). The xanthine oxidase inhibitory activities of the fruiting bodies, mycelia, and culture extract were 85.47%, 78.13%, and 72.49% at 400 μg/mL, respectively. Overall, the fruiting body extract has better anti-acetylcholinesterase, antioxidant and xanthine oxidase inhibitory activities than those from mycelia and culture filtrate.
목차
ABSTRACT Introduction Materials and Methods Specimens and fungal isolate Preparation of the Extracts Fruiting body extract Mycelia extract Culture filtrate Assay for total phenolics Assay for total flavonoid Scavenging effect on DPPH radicals Chelating effect on ferrous ions Xanthine oxidase inhibitory activity Acetylcholinesterase inhibitory activity Results and Discussions Total phenolics and flavonoid DPPH scavenging effect on free radicals Chelating effects on ferrous ions Xanthine oxidase inhibitory activity Acetylcholinesterase inhibitory activity Acknowledgemen References