Earticle

초록

영어

Embryonic genome activation (EGA) is a highly complex phenomenon that is controlled at various levels. New studies have ascertained some molecular mechanisms that control EGA in several species; it is apparent that these same mechanisms regulate EGA in all species. Protein phosphorylation, DNA methylation and histone modification regulate transcriptional activities, and mechanisms such as ubiquitination, SUMOylation and microRNAs post-transcriptionally regulate development. Each of these regulations is highly dynamic in the early embryo. A better understanding of these regulatory strategies can provide the possibility to improve the reproductive properties in mammals such as pigs, to develop methods of generating high-quality embryos in vitro, and to find markers for selecting developmentally competent embryos.

목차

ABSTRACT
 INTRODUCTION
 GENERAL TRANSCRIPTION FACTORS
 RNA POLYMERASE II CTD
 EMBRYONIC GENOME ACTIVATION
  EGA and Maternal mRNA Degradation
  CTD Phosphorylation and EGA
 RNA POLYMERASE II CTD KINASE
  P-TEFb
  TFIIH
  RNA POLYMERASE CTD PHOSPHATASE
 CONCLUSIONS AND PERSPECTIVES

키워드

저자

• Reza K. Oqani [ Department of Animal Science & Biotechnology, Research Center for Transgenic Cloned Pigs, Chungnam National University ]
• Jung Won Kang [ Department of Animal Science & Biotechnology, Research Center for Transgenic Cloned Pigs, Chungnam National University ]
• Tao Lin [ Department of Animal Science & Biotechnology, Research Center for Transgenic Cloned Pigs, Chungnam National University ]
• Jae Eun Lee [ Department of Animal Science & Biotechnology, Research Center for Transgenic Cloned Pigs, Chungnam National University ]
• Dong-Il Jin [ Department of Animal Science & Biotechnology, Research Center for Transgenic Cloned Pigs, Chungnam National University ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  Reproductive & developmental biology

• 간기

  계간

• pISSN

  1738-2432

• eISSN

  2288-0151

• 수록기간

  1977~2018

• 십진분류

  KDC 527 DDC 636