Earticle

초록

영어

The majority of early embryonic mortality in pregnancy occurs during the peri-implantation stage, suggesting that this period is important for conceptus viability and the establishment of pregnancy. Successful establishment of pregnancy in all mammalian species depends on the orchestrated molecular events that transpire at the conceptus- uterine interface during the peri-implantation period. This maternal-conceptus interaction is especially crucial in pigs because in them non-invasive epitheliochorial placentation occurs, in which the pre-implantation phase is prolonged. During the pre-implantation period, conceptus survival and the establishment of pregnancy are known to depend on the developing conceptus receiving an adequate supply of histotroph, which contains a wide range of nutrients and growth factors. Evidence links growth factors including epidermal growth factor (EGF), insulin-like growth factor-I (IGF-I), vascular endothelial growth factor (VEGF), and colony-stimulating factor 2 (CSF2) to embryogenesis or implantation in various mammalian species; however, in the case of pig, little is known about such functions of these growth factors, especially their regulatory mechanisms at the maternal-conceptus interface. Our research group has presented evidence for promising growth factors affecting cellular activities of primary porcine trophectoderm (pTr) cells, and we have identified potential intracellular signaling pathways responsible for the activities induced by these factors. Therefore, this review focuses on promising growth factors at the maternal-conceptus interface regulating the development of the porcine conceptus and playing pivotal roles in implantation events during early pregnancy in pigs.

목차

ABSTRACT
 INTRODUCTION
 EVENTS DURING THE EARLY PREGNANCY
  Pre-Implantation Period
  Opening of the Implantation Window and Implantation
 PHYSIOLOGY OF THE PORCINE CONCEPTUS DURING PERI-IMPLANTATION
  Early Conceptus Development
  Maternal Recognition of Pregnancy
  Conceptus Trophoblastic Elongation
  Conceptus Apposition and Attachment to the Uterine Luminal Epithelium
 UTERINE MICROENVIRONMENT DURING EARLY PREGNANCY
  Maternal-Conceptus Interactions
  Embryonic Factors
  Uterine Factors
 GROWTH FACTORS AND CYTOKINES REGULATINGCONCEPTUS CELLULAR PROCESSES
 MECHANISMS OF EGF, IGF-I, VEGF AND CSF2 ON DEVELOPMENT OF PORCINE CONCEPTUS TROPHECTODERM
 CONCLUSION
 REFERENCES

키워드

저자

• Wooyoung Jeong [ Department of Animal Resources Science, Dankook University, Cheonan 330-714, Korea ]
• Gwonhwa Song [ Department of Biotechnology, Korea University, Seoul 136-713, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  Reproductive & developmental biology

• 간기

  계간

• pISSN

  1738-2432

• eISSN

  2288-0151

• 수록기간

  1977~2018

• 십진분류

  KDC 527 DDC 636