Earticle

초록

영어

For successful embryo implantation, the communication of the maternal endometrium with the conceptus trophectoderm is required essentially. In pigs, conceptuses undergo morphological change in length to enlarge the physical contact area with the maternal endometrium and secrete estrogen to induce the maternal recognition of pregnancy during the peri-implantation period. Conceptus-derived estrogen prevents luteolysis by conversion in direction of PGF2α secretion from the uterine vasculature to the uterine lumen as well as it affects on expression of the uterine endometrial genes. In addition to estrogen, conceptuses release various signaling molecules, including cytokines, growth factors, and proteases, and, in response to these signaling molecules, the maternal uterine endometrium also synthesizes many signaling molecules, including hormones, cytokines, growth factors, lipid molecules, and utilizes ions such as calcium ion by calcium regulatory molecules. These reciprocal interactions of the conceptus trophectoderm with the maternal uterine endometrium make development and successful implantation of embryos possible. Thus, signaling molecules at the maternal-conceptus interface may play an important role in the implantation process. This review summarized syntheses and functions of signaling molecules at the maternal-conceptus interface to further understand mechanisms of the embryo implantation process in pigs.

목차

ABSTRACT
 INTRODUCTION
 MEDIATORS REGULATING THE IMPLANTATION PROCESS AT MATERNAL-CONCEPTUS INTERFACE DURING PREGNANCY IN PIGS
  Hormones
  Progesterone
  Estrogen
  Oxytocin
  Luteinizing Hormone
  Proalctin
 Cytokines
  Interleukin 1-Beta
  Interferons
 Growth Factors
  Epidermal Growth Factors
  Fibroblast Growth Factors
  Insulin-Like Growth Factors
  Vascular Endothelial Growth Factor
 Other Lipid Mediators
  Prostaglandins
  Lysophosphatidic Acids
  Calcium Ions
 CONCLUSION
 REFERENCES

키워드

저자

• Yohan Choi [ Department of Biological Science and Technology and IPAID, Yonsei University, Wonju 220-710, Korea ]
• Heewon Seo [ Department of Biological Science and Technology and IPAID, Yonsei University, Wonju 220-710, Korea ]
• Inkyu Yoo [ Department of Biological Science and Technology and IPAID, Yonsei University, Wonju 220-710, Korea ]
• Jisoo Han [ Department of Biological Science and Technology and IPAID, Yonsei University, Wonju 220-710, Korea ]
• Hwanhee Jang [ Department of Biological Science and Technology and IPAID, Yonsei University, Wonju 220-710, Korea ]
• Minjeong Kim [ Department of Biological Science and Technology and IPAID, Yonsei University, Wonju 220-710, Korea ]
• Hakhyun Ka [ Department of Biological Science and Technology and IPAID, Yonsei University, Wonju 220-710, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  Reproductive & developmental biology

• 간기

  계간

• pISSN

  1738-2432

• eISSN

  2288-0151

• 수록기간

  1977~2018

• 십진분류

  KDC 527 DDC 636