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Citrus Peel Extract Inhibits LPS-induced Cytokines Secretion in Macrophage
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- 발행기관
- 보안공학연구지원센터(IJBSBT) 바로가기
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- 간행물
- International Journal of Bio-Science and Bio-Technology SCOPUS 바로가기
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- 통권
- Vol.6 No.1 (2014.01)바로가기
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- 페이지
- pp.11-20
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- 저자
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- 언어
- 영어(ENG)
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- URL
- https://www.earticle.net/Article/A214622
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
- 영어
- Citrus peel is a useful research resource containing important physiological function materials. In this study, anti-inflammatory effects of Citrus peel extracts were identified in LPS-induced macrophage cells. After the pretreatment of lipopolysarcharide (LPS), inhibitory effects of nitric oxide (NO), inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2) and pro-inflammatory cytokines, tumor necrotic factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1 (IL-1), production were measured according to the treatment of citrus peel extracts. Study results showed approximately 40% inhibition of NO production but no concentration-dependent effects when citrus peel extracts were treated. According to the results of inhibitory effects of pro-inflammatory cytokines production, IL-6 had about 44% inhibition of production, TNF-α had about 13% inhibition of production, and IL-1 had no inhibition of production. According to western blot results, iNOS protein’s expression was slightly decreased. Also, COX-2 protein’s expression was observed to be slightly decreased in cells treated with citrus peels as iNOS’s result.
목차
Abstract
1. Introduction
2. Materials and Methods
2.1. Manufacture of extracts
2.2. Cell culture
2.3. MTT cell viability assay
2.4. NO measuring generation inhibitory activity
2.5. Enzyme linked-immunosorbant assay (ELISA)
2.6. Immunoblot analysis
2.7. Statistical analysis
3. Results
3.1. Effect of citrus peels extracts on cellular cytotoxicity
3.2. Inhibitory effect of citrus peels extracts on LPS-induced NO production
3.3. Inhibitory effect of citrus peels extracts on LPS-induced iNOS and COX-2
3.4. Inhibitory effect of citrus peels extracts on LPS-induced cytokine production
4. Discussion
5. Conclusion
References
키워드
Citrus peel NO TNF-α IL-6 iNOS COX-2저자
간행물 정보
발행기관
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- 발행기관명
- 보안공학연구지원센터(IJBSBT) [Science & Engineering Research Support Center, Republic of Korea(IJBSBT)]
- 설립연도
- 2006
- 분야
- 공학>컴퓨터학
- 소개
- 1. 보안공학에 대한 각종 조사 및 연구 2. 보안공학에 대한 응용기술 연구 및 발표 3. 보안공학에 관한 각종 학술 발표회 및 전시회 개최 4. 보안공학 기술의 상호 협조 및 정보교환 5. 보안공학에 관한 표준화 사업 및 규격의 제정 6. 보안공학에 관한 산학연 협동의 증진 7. 국제적 학술 교류 및 기술 협력 8. 보안공학에 관한 논문지 발간 9. 기타 본 회 목적 달성에 필요한 사업
간행물
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- 간행물명
- International Journal of Bio-Science and Bio-Technology
- 간기
- 격월간
- pISSN
- 2233-7849
- 수록기간
- 2009~2016
- 등재여부
- SCOPUS
- 십진분류
- KDC 505 DDC 605
이 권호 내 다른 논문 / International Journal of Bio-Science and Bio-Technology Vol.6 No.1
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