Malg-Um Lim, Sung-Youn Heo, Mi-Ran Hwang, Yoon-Ju Na, Ji-Su Kim, Sun-Uk Kim, Kyu-Tae Chang, Young-Kug Choo
언어
영어(ENG)
URL
https://www.earticle.net/Article/A212765
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
영어
Gangliosides are sialic acid-containing glycosphingolipids that are abundant in neurons and have a variety of functions in developing and mature tissue. Mini-pig neural stem cells contained GM2 and GM3 as major gangliosides. In order to study their distribution in mini-pig neural stem cells and its possible changes during the differentiation of neuronal cells, cells were stained with specific monoclonal antibodies against 11 ganglio-series gangliosides including those mentioned above. GM2 and GM3 were expressed in a spatio-temporally different manner during differentiation of mini-pig neural stem cells, but other gangliosides were not immunohistochemically detected. These results suggest that ganglioside GM2 and GM3 play an important role in the regulation of neuronal differentiation of mini-pig neural stem cells through the activation of retionic acid (RA) and basic fibroblast growth factor (bFGF).
저자
Malg-Um Lim [ Dept. of Biological Scienc, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 570-749, Korea ]
Sung-Youn Heo [ Dept. of Biological Scienc, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 570-749, Korea ]
Mi-Ran Hwang [ Dept. of Biological Scienc, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 570-749, Korea ]
Yoon-Ju Na [ Dept. of Biological Scienc, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 570-749, Korea ]
Ji-Su Kim [ ational Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), O-chang, Chungbuk 363-883, Korea ]
Sun-Uk Kim [ ational Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), O-chang, Chungbuk 363-883, Korea ]
Kyu-Tae Chang [ ational Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), O-chang, Chungbuk 363-883, Korea ]
Young-Kug Choo [ Dept. of Biological Scienc, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 570-749, Korea ]
본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.