Earticle

초록

영어

To date, many efforts have been made to detect lectins in cells by using single imaging techniques. However, only a few dual-labeled glycan-based probes, which integrate advantageous features of two imaging methods to enhance the visualization of biological processes associated with lectins in cells, have been reported. Herein we describe the synthesis of dual fluorescence and magnetic resonance imaging agent conjugated neoglycopeptides and their application in the simultaneous imaging of lectins in mammalian cells. The dual-labeled neoglycopeptides bind to lectins on cell surfaces and subsequently enter the cells via lectin-mediated endocytosis. The results of these efforts show that the novel dual-labeled neoglycopeptides are effective fluorescence and MR imaging agents for monitoring biological processes associated with lectins.

저자

• Xizhe Tian [ Department of Chemistry, Yonsei University, Seoul, 120-749, Korea ]
• Kyung-Hwa Baek [ Department of Chemistry, Yonsei University, Seoul, 120-749, Korea ]
• Jaeyoung Pai [ Department of Chemistry, Yonsei University, Seoul, 120-749, Korea ]
• Injae Shin [ Department of Chemistry, Yonsei University, Seoul, 120-749, Korea ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국당과학회 학술대회

• 간기

  연간

• 수록기간

  2006~2022

• 십진분류

  KDC 517 DDC 614