김영완, Chao Li, Hee-Jeong Ahn, Min-Su Kim, Eui-Jeon Woo, Jin-Hyo Kim, Jun-Hyuck Jang
언어
영어(ENG)
URL
https://www.earticle.net/Article/A212731
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원문정보
초록
영어
As one of the most important compounds in nature, carbohydrates have attracted much attention in the fields of chemical biology, therapeutics, synthetic chemistry and so on. During the last 15 years, engineered glycosidases, including glycosynthases, thioglycoligases and O-glycoligases, have emerged as very powerful tools to address the synthesis of various functional carbohydrates, such as oligosaccharides, glycolipids and glycoproteins. These mutated glycosidase, whose catalytic residue (nucleophile or general acid/base) is replaced by an inactive residue, loss their hydrolytic activity and show significantly transglycosylation activities. Many elegant cases have been reported so far. Here, the different catalytic mechanisms and advances of engineered glycosidases in the synthesis of carbohydrates were summarized.
목차
1. 학력 2. 경력 3. 주요 연구분야/공동연구 가능분야 4. 수행중인 연구과제 5. 대표 논문/특허 6. 보유 기술, 장비 혹은 제공 가능한 물질(표준물질, 저해제, 효소, 항체, 유전자, 세포주등) Exploring and Exploiting of Enzymatic Tools for Efficient Synthesis of Oligosacchrides Acknowledgement Reference
저자
김영완 [ Young-Wan Kim | 고려대학교 과학기술대학 식품생명공학과, 부교수 ]
Chao Li [ Department of Food and Biotechnology, Korea University, Sejong, 339-700, Korea ]
Hee-Jeong Ahn [ Department of Food and Biotechnology, Korea University, Sejong, 339-700, Korea ]
Min-Su Kim [ Department of Food and Biotechnology, Korea University, Sejong, 339-700, Korea ]
Eui-Jeon Woo [ Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon, 305-806, Korea ]
Jin-Hyo Kim [ Chemical Safety Division, Rural Development Administration, Suwon, 441-701, Korea ]
Jun-Hyuck Jang [ Department of Food and Biotechnology, Korea University, Sejong, 339-700, Korea ]
본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.