Most cancer cells produce energy by glycolysis followed by fermentation in the cytosol, even though they exist in the presence of oxygen. But the research about cancer metastasis has been limited to hypoxia condition until now. Interestingly it was reported that O-GlcNAc modification on protein was significantly increased under hypoglycemic condition. O-GlcNAcylation is one of the post-translational protein modification and it appears to be involved in many different cellular activities. And it was thought that O-GlcNAcylation is also related with EMT. In our study, we want to examine whether hypoglycemic condition can induce cancer metastasis and it is related to increased O-GlcNAc modification or not. So we focused on EMT to visualize cancer metastasis. We found that the amount of several EMT marker were changed under hypoglycemic condition in cancer cell. And one of them was O-GlcNAcylated. These findings tell us that hypoglycemic condition can be closely connected with cancer metastasis via O-GlcNAclation. So we suggest possibilities that hypoglycemic condition induced EMT in cancer cell and it related with increased O-GlcNAc modification.
저자
Eunah Kim [ Department of Integrated OMICS for Biomedical Sciences, Graduate School, Yonsei University ]
Jin Won Cho [ Department of Integrated OMICS for Biomedical Sciences, Graduate School, Yonsei University, Department of Biology, Yonsei University, Seoul 120-749, Korea ]
본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.