Earticle

초록

영어

Background: Malnutrition of inpatients has been associated with higher morbidity, mortality, cost, and longer hospitalstay. Total parenteral nutrition (TPN) therapy plays an important role in decreasing morbidity and mortality among criticalinpatients in hospitals, and has been commonly used to improve clinical outcomes. However, only a few studieswere conducted regarding patients` nutritional improvement by TPN. Method: This study therefore evaluated thechanges in nutritional parameters by TPN therapy for early malnourished inpatients. Data from early malnourished inpatientswho were treated with TPN therapy between January 2012 and June 2013 at the ○○ university Hospital werestudied retrospectively. Information regarding sex, age, underlying diseases, division, TPN (peripheral and central), andchanges in nutritional parameters were collected by reviewing electronic medical records. The criteria for evaluation ofthe changes in nutritional parameters were included physical marker, body mass index (BMI), and biochemical markers,including albumin (Alb), total lymphocyte count (TLC), and cholesterol. Nutritional parameters were collected threetimes: pre-TPN, mid-TPN and end-TPN. A total of 149 patients (peripheral, 97; central, 52) was evaluated. Results: In allpatients, the malnutrition number was significantly decreased following the complete TPN therapy (peripheral patients, pre-TPN: 3.33±0.12, mid-TPN : 3.06±0.17, and end-TPN: 2.85± 0.21 (p < 0.05); central patients, pre-TPN: 3.38±0.11, mid-TPN: 3.06±0.13, and end-TPN: 2.75 ±0.21 (p < 0.05). The malnutrition number means number of nutrition parametersbelow normal range of malnutrition. In addition, all of the four nutritional parameters (BMI, Alb, TLC and cholesterol)were increased with duration of TPN periods for all patients, and the changes in the early stage were larger than in thelate stage (p < 0.05). The nutritional parameters of non -cancer patients were increased to a greater extent compared tocancer patients with longer TPN therapy, but it was not significant. The nutritional parameters of younger patients (50-60 years) were also increased more than of older patients (70-80 years), but it was not significant. Conclusion: In conclusion,the TPN therapy decreases malnutritional status and improves nutritional parameters in malnourished patients,thereby decreasing morbidity and mortality. The combined evaluation of all four nutritional parameters is more accuratefor nutritional assessment than a single one.

목차

Abstract
 연구방법
  연구 대상
  자료수집 및 조사항목
  연구대상 약물
  자료분석
  통계 처리
 연구 결과
  연구대상자들의 기본특성
  연구대상자들의 해당 진료과와 질환의 분포
  연구대상자들의 영양부족지표 변화
  전체 연구대상자들의 4가지 영양지표의 변화
  연구 대상자들의 질환(암의 유무)에 따른 4가지 영양지표의 변화
  연구 대상자들의 연령에 따른 4가지 영양지표의 변화
 고찰
 참고문헌

키워드

저자

• 차윤영 [ Cha Yun Young | 충북대학교 약학대학 ]
• 김정태 [ Jung Tae Kim | 경희대학교 약학대학 ]
• 임성실 [ Lim Sung Cil | 가톨릭대학교 약학대학 ] Correspondence to

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국임상약학회지 [Korean Journal of Clinical Pharmacy]

• 간기

  계간

• pISSN

  1226-6051

• 수록기간

  1991~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 518 DDC 615