Earticle

초록

영어

While high-dose ionizing radiation results in long term cellular cytotoxicity, chronic low-dose (<0.2 Gy) of X- or γ-ray irradiation can be beneficial to living organisms by inducing radiation hormesis, stimulating immune function, and adaptive responses. During chronic low-dose-rate radiation (LDR) exposure, whole body of mice is exposed to radiation, however, it remains unclear if LDR causes changes in gene expression of the whole brain. Therefore, we aim to investigate expressed genes (EGs) and signaling pathways specifically regulated by LDR-irradiation (137Cs, a cumulative dose of 1.7 Gy for total 100 days) in the whole brain. Using microarray analysis of whole brain RNA extracts harvested from ICR and AKR/J mice after LDR- irradiation, we discovered that two mice strains displayed distinct gene regulation patterns upon LDR-irradiation. In ICR mice, genes involved in ion transport, transition metal ion transport, and developmental cell growth were turned on while, in AKR/J mice, genes involved in sensory perception, cognition, olfactory transduction, G- protein coupled receptor pathways, inflammatory response, proteolysis, and base excision repair were found to be affected by LDR. We validated LDR-sensitive EGs by qPCR and confirmed specific upregulation of S100a7a, Olfr624, and Gm4868 genes in AKR/J mice whole brain. Therefore, our data provide the first report of genetic changes regulated by LDR in the mouse whole brain, which may affect several aspects of brain function.

목차

Abstract
 1. INTRODUCTION1)
 2. MATERIALS AND METHODS
 3. RESULTS AND DISCUSSION
 4. CONCLUSION
 Acknowledgements:
 REFERENCES

키워드

저자

• JIN JONG BONG [ Radiation Health Research Institute, Korea Hydro and Nuclear Power Co., Ltd. ]
• YU MI KANG [ Radiation Health Research Institute, Korea Hydro and Nuclear Power Co., Ltd. ]
• SEUNG JIN CHOI [ Radiation Health Research Institute, Korea Hydro and Nuclear Power Co., Ltd. ]
• DONG-KWON KIM [ Nuclear Environment Research Division, Korea Atomic Energy Research Institute ]
• KYUNG MI LEE [ Global Research Lab, BAERI Institute, Department of Biochemistry and Molecular Biology, Korea University College of Medicine ]
• HEE SUN KIM [ Radiation Health Research Institute, Korea Hydro and Nuclear Power Co., Ltd. ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  방사선방어학회지 [Journal of Radiation Protection and Research]

• 간기

  계간

• pISSN

  2508-1888

• 수록기간

  1976~2026

• 등재여부

  KCI 등재,SCOPUS

• 십진분류

  KDC 559 DDC 629