Earticle

초록

영어

Alternative splicing (AS) and Gene duplication are two well known evolutionary and ubiquitous mechanisms. Both have the common gist for conveying the functional diversity by means of escalating gene variegation. The objective of this study is to understand the established hidden relationship between both of these mechanisms to find the answer for the long standing puzzle circumventing the evolution of genome size while utilizing the computational power. We investigated that the alternative splicing can promise to unveil the nature as well as operation of cellular codes meticulously which play inevitable role of combinations of regulatory elements in pre-mRNA. This study also describe in detail of the cellular complements of splicing regulators, which collectively establish regulated splicing pathways. We have proposed a computational framework based on subset theory to address a part of the inexplicable functional diversity paradox which is also known as c-value enigma. The operational detail of this framework has been discussed to give an insight into the possible solution towards the problem of more proteins than their corresponding genetic material.

목차

Abstract
 1. Introduction
 2. Methodology
  2.1 Statement of Alternating Splicing Problem
 3. Results and Discussion
 References

키워드

저자

• Muhammad Naeem [ Department of Computer Science, Mohammad Ali Jinnah University ]
• Saira Gillani [ Centre of Research in Networks & Telecom (CoReNeT), Mohammad Ali Jinnah University Islamabad ]
• Sohail Asghar [ University Institute of Information Technology PMAS-Arid Agriculture University Rawalpindi ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  International Journal of Hybrid Information Technology

• 간기

  격월간

• pISSN

  1738-9968

• 수록기간

  2008~2016

• 십진분류

  KDC 505 DDC 605