Jong-Dae Kim, Kyeong-Min Nam, Yu-Seop Kim, Chan-Young Park, Hye-Jeong Song
언어
영어(ENG)
URL
https://www.earticle.net/Article/A207166
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
영어
This paper develops a new diagnosis model using urine biomarker proteins for early ovarian cancer diagnosis. The optimum marker combination that best classifies the benign tumor and cancer was determined from 15 biomarkers and the performance was evaluated. Samples consist of 121 patients with benign tumor, and 55 patients with ovarian cancer. 15 urine biomarkers showing specific reaction to ovarian cancer was the concentration value obtained from xMAP™ bead-based technology (Luminex Corp.). The area under the curve (AUC) of ROC was evaluated to determine the optimum marker combination showing the best performance in difference between patients diagnosed with ovarian cancer and benign. The performance of the selected combination was confirmed with logistic regression. For each combination of two, three, and four biomarkers showed the highest AUC of 85.71%, 86.38%, and 86.7%, respectively. The highest accuracy of distinguishing benign to cancer was 82.58% for a single biomarker, and 84.27%, 84.83%, and 85.29% for each combination of two, three, and four biomarkers, respectively. It was confirmed that the ovarian cancer diagnosis model utilizing the optimum biomarker combination determined in this research showed better performance and higher accuracy than using a single biomarker.
보안공학연구지원센터(IJBSBT) [Science & Engineering Research Support Center, Republic of Korea(IJBSBT)]
설립연도
2006
분야
공학>컴퓨터학
소개
1. 보안공학에 대한 각종 조사 및 연구
2. 보안공학에 대한 응용기술 연구 및 발표
3. 보안공학에 관한 각종 학술 발표회 및 전시회 개최
4. 보안공학 기술의 상호 협조 및 정보교환
5. 보안공학에 관한 표준화 사업 및 규격의 제정
6. 보안공학에 관한 산학연 협동의 증진
7. 국제적 학술 교류 및 기술 협력
8. 보안공학에 관한 논문지 발간
9. 기타 본 회 목적 달성에 필요한 사업
간행물
간행물명
International Journal of Bio-Science and Bio-Technology
간기
격월간
pISSN
2233-7849
수록기간
2009~2016
등재여부
SCOPUS
십진분류
KDC 505DDC 605
이 권호 내 다른 논문 / International Journal of Bio-Science and Bio-Technology Vol.5 No.3