Earticle

초록

영어

New mesoporous silica nanoparticle (MSNs) with high surface area and pore volume has been synthesized successfully using TritonX-100 as main and Tween 60 as co-template (at various concentrations). Ibuprofen a water insoluble model drug was loaded into the synthesized silica nanoparticle and studied for sustained release capability. All the as synthesized and drug loaded nanoparticle were characterized using physicochemical techniques such as FTIR, Difuse reflectance UV spectroscopy(UV-DRS), Brunauer Emmett Teller (BET) technique, Differential Scanning Calorimetri ( DSC ),Thermo gravimetric analysis (TGA), powder XRD and scanning electron microscopy( SEM) for the morphology and drug loading. From the results it was noted that all the silica nanoparticle synthesized by sol-gel method were mesoporous with high surface area and pore volume (1024.3, 1056.2 and 1083.6 m2 g-1 and 0.9229, 0.9904 and 0.8468 for TW6-1rt, TW6-2rt and TW6-3rt respectively) and have the capability of up taking 32 % ibuprofen model drug further they shows initial burst release for 50h followed by sustained maintenance of dose even after 150h.

목차

Abstract
 1. Introduction
 2. Experimental
  2.1. Materials
  2.2. Synthesis of silica carrier
  2.3. Loading of DX
  2.4. Characterization
 3. Results and discussions
  3.1. Characterization
  3.2. Drug inclusion in the particles
  3.3. Dissolution studies
 4. Conclusions
 Acknowledgements
 References

키워드

저자

• Mani Ganesh [ Department of Chemical Engineering, Hanseo University ]
• Seung Gil Lee [ Department of Life Science, Hanseo University, Seosan-si 356-706, South Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  International Journal of Control and Automation

• 간기

  월간

• pISSN

  2005-4297

• 수록기간

  2008~2016

• 십진분류

  KDC 505 DDC 605