Earticle

초록

영어

Post-traumatic stress disorder (PTSD) is a condition which occurs after a person has experienced unusual stress. The neurons in the hippo-campus are especially vulnerable to the PTSD. In the present study, the effect of treadmill exercise on spatial learning memory and cell prolifer-ation in the hippocampus of rats with PTSD. Radial 8-arm maze test and immunohistochemistr for 5-bromo-2´-deoxyridine (BrdU) and double-cortin (DCX) were conducted for this experiment. For the inducing PTSD, the rats were exposure to 0.2 mA electric foot shock for 7 consecutive days. Electric foot shock continued 6 seconds, repeated 10 times with a 30 sec interval per one trial, and repeated 3 trials per day. The rats in the exercise groups were forced to run on a motorized treadmill for 30 min once a day for 4 weeks, stating one day after finishing last electric food shock. Presently, the PTSD rats showed longer time of successful per-formance, higher error number, and lower correct number in the radi-al-8-arm maze test. Cell proliferation and DCX expression in the hippo-campal dentate gyrus were suppressed in the PTSD rats. In contrast, treadmill exercise alleviated PTSD-induced impairment of spatial learn-ing memory. The rats performed treadmill exercise showed longer time of successful performance, higher error number, and lower correct num -ber in the radial-8-arm maze test. Treadmill exercise also enhanced cell proliferation and DCX expression in the hippocampal dentate gyrus of PTSD rats. The present study demonstrated that treadmill exercise ameliorated PTSD-induced memory impairment through enhancing cell prolif- eration in the hippocampus.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Experimental animals and treatments
  Induction of PTSD
  Exercise protocol
  Radial 8-arm maze test
  Tissue preparation
  BrdU immunohistochemistry
  DCX immunohistochemistry
  Data analysis
 RESULTS
  Effect of treadmill exercise on spatial learning memory in the radial 8-arm maze test
  Effect of treadmill exercise on cell proliferation in the hippocampal dentate gyrus
  Effect of treadmill exercise on DCX expression in the hippocampal dentate gyrus
 DISCUSSION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Bo-Kyun Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Jin-Hee Seo [ Division of Sports Science, Baekseok University, Cheonan, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613