Earticle

초록

영어

Substantia nigra and striatum are vulnerable to hypoxic ischemia brain injury. Physical exercise promotes cell survival and functional recovery after brain injury. However, the effects of treadmill exercise on nigro-stri-atal dopaminergic neuronal loss induced by hypoxic ischemia brain in-jury in neonatal stage are largely unknown. We determined the effects of treadmill exercise on survival of dopamine neurons in the substantia nigra and dopaminergic fibers in the striatum after hypoxic ischemia brain injury. On postnatal 7 day, left common carotid artery of the neo-natal rats ligated for two hours and the neonatal rats were exposed to hypoxia conditions for one hour. The rat pups in the exercise groups were forced to run on a motorized treadmill for 30 min once a day for 12 weeks, starting 22 days after induction of hypoxic ischemia brain injury. Spatial learning ability in rat pups was determined by Morris water maze test after last treadmill exercise. The viability of dopamine neurons in the substantia nigra and dopamine fibers in the striatum were analyzed us-ing immunohistochemistry. In this study, hypoxic ischemia injury caused loss of dopamine neurons in the substantia nigra and dopaminergic fi -bers in the striatum. Induction of hypoxic ischemia deteriorated spatial learning ability. Treadmill exercise ameliorated nigro-striatal dopami-nergic neuronal loss, resulting in the improvement of spatial learning ability. The present study suggests the possibility that treadmill exercise in early adolescent period may provide a useful strategy for the recov-ery after neonatal hypoxic ischemia brain injury.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Animals and treatments
  Induction of hypoxic ischemia brain injury
  Treadmill exercise protocol
  Morris water maze test
  Tissue preparation
  Immunohistochemistry for TH
  Statistical analysis
 RESULTS
  Effect of treadmill exercise on spatial learning ability
  Effect of treadmill exercise on the TH expression in the substantia nigra
  Effect of treadmill exercise on the dopamine expression in the substantia nigra
  Effect of treadmill exercise on the TH expression in the striatum
 DISCUSSION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Chang-Youl Park [ Department of Emergency Medical Technology, College of Health Service, Jeonju Vision University, Jeonju, Korea ]
• Shin-Ho Lee [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Bo-Kyun Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Mal-Soon Shin [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Chang-Ju Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Hong Kim [ Department of Oriental Sports Medicine, College of Health and Therapy, Daegu Haany University, Gyeongsan, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613