We investigated whether the decreased cell proliferation resulting from pups born from maternal stress during pregnancy is enhanced by the treadmill exercise. It is showed that early adverse experiences-induced the dysregulation of the Ki-67 and NPY expression is reversed by exercise. Rats of stress-applied groups were exposed to a 95-desibel (dB) supersonic machine sound for 1 h, while rats of the control group were left undisturbed. The offspring were divided into six groups. Pups of the exercise groups were made to run on treadmill for 30 min once a day for 7 consecutive days. The analysis brain tissue was used by immunohistochemistry for the expression of Ki-67 and NPY. We also found that postnatal rat pups might be significant reversed by treadmill exercise on the prenatal stress-induced decrease in the hippocampal cell proliferation during pregnancy. In conclusions, we investigated that mild exercise was a better strategy to manage foe postnatal pups with early adverse stress-induces suppression of cell proliferation in prenatal stress during pregnancy
목차
Ⅰ. Introduction Ⅱ. Materials and Methods 1. Animals and Treatments 2. Treadmill Exercise Protocol 3. Tissue Preparation 4. Immunohistochemistry 5. Data Analysis Ⅲ. Results 1. Effect of postnatal exercise on hippocampal cell proliferation in 4weeks-old pups 2. Effect of postnatal exercise on hippocampal NPY expression in 4weeks-old pups Ⅳ. Discussion Ⅴ. Conclusion Acknowledgements References ABSTRACT
현대사회에 있어서 신체활동 연구의 주요 탐구과제는 ‘신체활동을 통한 교육’으로부터 ‘인간의 기본적인 움직임’을 목표로 하는 스포츠적인 움직임을 중심으로 한 생명 활동의 개념으로 급속히 변화되고 있는 추세이다. 이러한 환경변화에 대응하기 위하여 본학회는 ‘체육’적인 요소에서 ‘스포츠’적인 요소를 중심으로 한 학문적 정체성을 견고히 하고, 정기적인 학술지 발간과 학술활동을 통해 한국스포츠츠 문화의 발전과 학문적인 발전에 기여하는데 그 목적이 있다.