Earticle

초록

영어

Background: Prevalence of depression comorbid with neurologic disorders such as Alzheimer' disease (AD), Parkinson's disease (PD) and vascular dementia (VD) is higher than that of primary depression. Antidepressant medications, suggested by many researches for depression comorbid with neurologic disorders such as AD, PD and VD, are mainly selective serotonin reuptake inhibitors (SSRI). Objective: The primary objective of this study is the evaluation of antidepressant drug therapy for AD, PD and VD. Method: This study was a retrospective study based on medical records, carried out for 3 years and 6 months (Jan. 2007~Jul. 2010). Patients, diagnosed as comorbid depression through Beck Depression Inventory (BDI), Cornell Depression Scale (CDS), Geriatric Depression Scale (GDS) among neurologic out-patients of Chungnam National University Hospital because of AD, PD and VD, were selected. The results were evaluated by efficacy and safety of antidepressant drug therapy. Results: In result, the prescribing rates of antidepressants were 30%, 55% and 40% for each AD, PD and VD. Depression cure rates of patients receiving antidepressants vs patients not receiving antidepressants were 40% vs 39%, 33% vs 23% and 38% vs 30% for AD, PD and VD. The frequencies of prescriptoin of SSRI were 21%, 11% and 27% for each AD, PD and VD. The frequencies of prescriptoin of benzodiazepine (BZD) was 61%, 82% and 61% for each AD, PD and VD. The ratio of single BZD prescription was more than that of combination prescription of antidepressants. Tricyclic antidepressants (TCA) were rarely prescribed. The rate of patients with BZD-related side effects was 54%. The most frequent side effects of BZD were dizziness (30%), drowsiness (21%) and headache (16%). Side effects of SSRI were rare. Conclusion: In conclusion, the frequencies of prescription of antidepressants were not common for AD, PD and VD. There was little difference in depression cure rate between patient receiving antidepressants and not receiving. Even though SSRI has to be the highest priority of usage, the frequencies of prescription of SSRI were lower than those of BZD. Additional researches and efforts are required to improve antidepressant drug therapy for neurologic disorders such as AD, PD and VD.

목차

ABSTRACT
 연구 방법
  연구 대상 및 기간
  조사 방법
  연구 대상 환자 기본 정보(Baseline)
  연구 대상 환자의 우울증 검사 도구 및 기준
 연구 결과 및 고찰
  연구 대상 환자군의 특성
  항우울 약물 처방의 빈도
  항우울 약물의 효과
  항우울 약물 각각의 처방 빈도
  병용을 고려한 항우울 약물의 처방율
  AD, PD 또는 VD 질환별 항우울 약물 치료의 지침과 현황 비교
  항우울 약물의 안전성 평가
 결론
 감사의 말씀
 참고문헌

키워드

저자

• 이효진 [ Hyo Jin Lee | 충북대학교 약학대학 임상약학실 ]
• 이옥상 [ Ok Sang Lee | 충북대학교 약학대학 임상약학실 ]
• 정선회 [ Sun Hoi Jung | 충북대학교 약학대학 임상약학실 ]
• 박미숙 [ Mi Sook Park | 충남대학교병원 약제부 ]
• 임성실 [ Sung Cil Lim | 충북대학교 약학대학 임상약학실 ] Correspondence to

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국임상약학회지 [Korean Journal of Clinical Pharmacy]

• 간기

  계간

• pISSN

  1226-6051

• 수록기간

  1991~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 518 DDC 615