Junhong JEONG, Hyun Gyu LIM, Sang Woo SEO, Gyoo Yeol JUNG
언어
영어(ENG)
URL
https://www.earticle.net/Article/A198002
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원문정보
초록
영어
3-hydroxypropionic acid (3-HP), also called as hydracrylic acid, is one of the valuable platform chemicals and widely used in industrial application. As chemical synthesis of 3-HP requires expensive starting materials and high energy consuming process, its production through microorganism based bio-process has been developed. Although one of the recent reports showed commercially available 3-HP production in Escherichia coli, with heterologous enzyme expression and process optimization, there is still room for improvement on its productivity and titer. In this research, glycerol which is a waste from bio-fuel production process was used as a substrate as well as sole carbon source and novel pathway was introduced and reconstructed in Escherichia coli for increased 3-HP production. 6 genes encoding pathway enzymes and the enzyme reactivase were expressed under constitutive strong promoters and maximized 5’-untranslated regions (5’-UTR). The engineered strain was able to convert glycerol to 3-HP successfully.
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동