Earticle

초록

영어

AKT protein family plays vital role in signal transduction by modification of substrate activity in regulation of metabolism, cell cycle progression, transcription, cell survival, motility, apoptosis, differentiation, angiogenesis and insulin responses. AKT protein family includes AKT1, AKT2 and AKT3 whereas AKT2 and AKT3 have one isomer each. In insulin signaling process, the insulin downstream action causes insulin receptor phosphorylation and subsequently insulin receptor substrate proteins formation. In the present study, we have performed phylogenetic analysis and conservation domain analysis for these AKT family members. We applied a pioneer and fast approach to study the structural, functional and phylogenetic relationship among the AKT family member. Our study shows a rapid way to calculate amino acid sequences in terms of evolutionary conservation rates and provides vital information about regions of structural and functional importance.

키워드

저자

• Narendra CHAUDHARY [ Department of Biotechnology, Chonnam National University, San 96-1, Dun-Duk Dong, Yeosu, Chonnam, 550-749, Korea. ]
• Permendra KUMAR [ School of Biosciences and technology, VIT University, Vellore -632014, Tamilnadu, India. ]
• Chiranjib CHAKRABORTY [ School of Biosciences and technology, VIT University, Vellore -632014, ]
• Jyoti BHARDWAJ [ Dept. of Biotechnology, Chonnam National University, San96-1, Dun-Duk Dong, Yeosu, Chonnam, 550-749, Korea. ]
• Hyo Jin SEO [ Dept. of Biotechnology, Chonnam National University, San96-1, Dun-Duk Dong, Yeosu, Chonnam, 550-749, Korea. ]
• Jong Deog KIM [ Dept. of Biotechnology, Research center on Anti-Obesity and Health Care (RCAOHC), Chonnam National University, San96-1, Dun-Duk Dong, Yeosu, Chonnam, 550-749, Korea. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576