Earticle

초록

영어

Natural products are growing interest in the field of nutrition and complementary medicine to prevent chronic illness or as treatment. We investigated the anti-cancer and anti-obesity properties of Green Tea seed saponin E1 (GTSSE1) on cancer cells and high fat diet induced obese mice, focusing the functional importance of GTSSE1.The anti-angiogenesis effect of GTSSE1 was examined on HUVECs. Anti-cancer and anti-obesity effect was investigated by using in-vitro and in-vivo system. Western blot analysis was also performed to evaluate the effect of GTSSE1 in angiogenic protein expression.GTSSE1 has least toxic effect on Human umbilical vein endothelial cells (HUVECs) in comparison to other saponins and significantly inhibited the proliferation of cancer cell lines. It inhibited the HUVECs cell tube formation through inhibition of VEGF-induced angiogenesis. The differentiating 3T3-L1 cells treated with various concentration of GTSSE1 had a visible decrease in lipid droplets formation measured by Oil Red O staining. Experiments in mice showed that GTSSE1 inhibits pancreatic lipase activity without hemolysis of erythrocytes, when administered orally. Also, it reduces the size of tumor in nude mice. From our investigation, we found GTSSE1 hasanti-cancer and anti-obesity properties. At dose-dependent concentration, it exerts pharmacological properties.

키워드

저자

• Narendra CHAUDHARY [ Department of Biotechnology, Chonnam National University, San96-1, Dun-Duk Dong, Yeosu, Chonnam, 550-749, Korea. ]
• Hyo Jin SEO [ Dept. of Biotechnology, Chonnam National University, San96-1, Dun-Duk Dong, Yeosu, Chonnam, 550-749, Korea. ]
• Min Yong KIM [ Dept. of Refrigeration Engineering, Chonnam National University, San96-1, Dun-Duk Dong, Yeosu, Chonnam, 550-749, Korea. ]
• Tai Sun SHIN [ Dept. of Food Science and Nutrition, Chonnam National University, San96-1, Dun-Duk Dong, Yeosu, Chonnam, 550-749, Korea. ]
• Jong Deog KIM [ Dept. of Biotechnology, Research center on Anti-Obesity and Health Care (RCAOHC), Chonnam National University, San96-1, Dun-Duk Dong, Yeosu, Chonnam, 550-749, Korea. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576