Earticle

초록

영어

In our present investigation, for the isolation of bioactive substances that could potentially inhibit the over expressions of matrix metalloproteinases, we worked on a marine derived fungal species Aspergillus. The fungal specimen was collected at Cheongsapo, Busan, South Korea. The culturing of the fungal strain was done at large scale and bioactive components were fractioned from the broth and the mycelium as well. The resultant extracts were fractioned with the aid of silica gel flash chromatography that resulted in fractions that were further purified by applying Octadecyl functionalized silica gel chromatography. Later the pure compounds from these fractions were obtained by using High-performance liquid chromatography (HPLC). The resultant pure compounds were analyzed for their respective structures and stereoscopic properties on the basis of Electron Ionization Mass Spectrometer spectrum (EI-MS), 1-dimensional and 2-dimensional Nuclear Magnetic resonance comprehensive analyses. The exploitation of marine fungal strain has yielded 2 compounds 2-Benzyl-4H-pyran-4-One (BHPO), and N-(1- (4-methoxy-2-oxo-2H-pyran-6-yl)-2-phenylethyl) acetamide (NOPPA) Pyrophen. Following to that, cell viability of these secondary metabolites were also evaluated to check their potentiality for in vitro tests. Our investigation suggests that there was no considerable cytotoxic effects exhibited by these metabolites and hence could be recommended for in vitro studies for their beneficial biological effects.

키워드

저자

• Noel vinay THOMAS [ Dept. of chemistry, Pukyong national university, Busan, 608-737. ]
• Se-Kwon KIM [ Dept. of chemistry, Pukyong national university, Busan, 608-737. ]
• Se-Kwon KIM [ Marine Bioprocess Research Center, Pukyong national university, Busan, 608-737. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576