Earticle

초록

영어

For developing medical adhesives, many challenging properties are required such as strong and long-term bonding with wet tissues, biocompatibility, and biodegradability. Hydrogel systems based on cross-linked polymeric materials which could provide both adhesion and cohesion in wet environment have been considered as a promising formulation of adhesives. Inspired by marine mussel adhesion, many researchers have tried to use 3,4-dihydroxy-phenylalanine (DOPA) residues as cross-linking mediators of hydrogel which is known to be able to achieve cohesive hardening as well as adhesive bonding with diverse surfaces. Herein, we developed new hydrogel system based on DOPA-containing recombinant mussel coating foot protein type 1 (fp-1). Cross-linking networks were established using oxdiation-induced DOPA-DOPA and iron (Fe3+)-mediated metal-DOPA coordination, which were confirmed by Raman spectroscopy and color change of the gels. Rheological analysis was performed to identify gelation time, frequency effect, and self-healing properties of gels. And also, adhesive strength of gels on porcine skin tissue surfaces in wet condition was measured by lap-shear test. Conclusively, our newly-developed hydrogel based on the DOPA chemistry of mussel adhesive proteins could be potentially used as tissue adhesives and sealants for future applications.

키워드

저자

• Bum Jin KIM [ School of Interdisciplinary Bioscience and Bioengineering. ]
• Dongyeop Xris OH [ School of Environmental Science and Technology, and Ocean Science and Technology Institute. ]
• Sangsik KIM [ School of Environmental Science and Technology, and Ocean Science and Technology Institute. ]
• Young Hoon SONG [ Department of Chemical Engineering. ]
• Dong Soo HWANG [ School of Environmental Science and Technology, and Ocean Science and Technology Institute. ]
• Hyung Joon CHA [ School of Interdisciplinary Bioscience and Bioengineering, Department of Chemical Engineering, and Ocean Science and Technology Institute, Pohang University of Science and Technology, Pohang, Korea. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576