Lysosomes are known widely as functional organelles in all eukaryotes by the Belgian cytologist Christian de Duve in 1949. These organelles contain various enzymes like lysozyme to degradate the molecules came from outside. On the other hands, the melanin is a ubiquitous pigment that has many different properties. Too much of melanin leads to make some problems so that we need to maintain amount of melanin normally. To use this functions in lysosomal enzymes, in our study, we found that lysosomes are able to decrease the color intensity of melanin. we measured that superficial intensity of lysosomal activities increased after we treated melanin. Besides when we treated lysosomes isolated from mammalian cells to melanocytes, quantities of melanin decreased. Additionally, to prove biologically lysosomes and melanin, we measured that amount of melanin on different passage. Melanin and lysosomes activities showed differently by aging. Therefore, in our results can show a relations between lysosomes and malenin. We assured that lysosomes are as a useful agent for decreasing amount of melanin.
키워드
melaninlysosomesaginglysosomal enzyme
저자
Dong Jun PARK [ Dept. of Bioprocess Engineering, Chonbuk National University, Jeonju, 664-14. ]
Yang Hoon KIM [ Dept. of Microbiology, Chongbuk National University, Cheongju, 361-763. ]
Jiho MIN [ Dept. of Bioprocess Engineering, Chonbuk National University, Jeonju, 664-14. ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
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