Earticle

초록

영어

The anti-inflammatory and anti-atopy effects of the Sargassum micracanthum ethanol extracts(SMEE) and water extracts(SMWE) and tuna eyeball oil extracts(TEOE). To evaluate the anti-inflammatory effects of SMEE, SMWE, and TEOE. The secretion of nitric oxide(NO), TNF-α, IL-6 and IL-1β was measured in LPS-induced RAW 264.7 cells by ELISA. The expression of iNOS, COX-2, and NF-κB p65 protein was studied by immunoblotting. The Balb/c mice were used for an in vivo acute toxicity test and ICR mice were purchased to evaluate croton oil-induced ear edema. It was confirmed that the NO and cytokines secretion significantly diminished compared to the positive control. The rate of formation of edema in the mouse ear was reduced at the highest dose tested compared to that in the control. Moreover, in acute toxicity test, no moralities occurred in mice administered 250 mg/kg body weight of SMEE, SMWE, and TEOE over 2 weeks observation period. To evaluate the anti-atopy effects of SMEE, SMWE, and TEOE, all extracts were applied to the dosal skin of 2,4dinitrochlorobenzene (DNCB)-induced Balb/c mice for an in vivo test. The secretion of IFN-γ, IL-4, and IgE was measured in splenocytes and serum by ELISA. In conclusion, these results suggest that SMEE, SMWE, and TEOE can inhibit inflammatory and atopic dermatitis by modulating cytokines, serum IgE and other substances secretion and improving skin symptoms.

키워드

저자

• Da Hyun JEONG [ Dept. of Food Science &Technology/Institute of Food Science, Pukyong National University, Busan, 608-737. ]
• Koth Bong Woo Ri KIM [ Institute of Fisheries Sciences/Pukyong National University, 474, Ilgwang-ro, Ilgwang-myeon, Gijang-gun, Busan. ]
• Bo Kyeong KANG [ Dept. of Food Science &Technology/Institute of Food Science, Pukyong National University, Busan, 608-737. ]
• Seul A JUNG [ Dept. of Food Science &Technology/Institute of Food Science, Pukyong National University, Busan, 608-737. ]
• Hyun Jee KIM [ Dept. of Food Science &Technology/Institute of Food Science, Pukyong National University, Busan, 608-737. ]
• Si Woo BARK [ Dept. of Food Science &Technology/Institute of Food Science, Pukyong National University, Busan, 608-737. ]
• Won Min PARK [ Dept. of Food Science &Technology/Institute of Food Science, Pukyong National University, Busan, 608-737. ]
• Bo Ram KIM [ Dept. of Food Science &Technology/Institute of Food Science, Pukyong National University, Busan, 608-737. ]
• Dong Hyun AHN [ Dept. of Food Science &Technology/Institute of Food Science, Pukyong National University, Busan, 608-737. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576