Systems biology is an interdisciplinary field of science that emphasizes on complex interactions within biological systems. It uses a more “complete” perspective approach to understand biological and biomedical contexts such molecular profiling technologies as microarray based transcriptomics and mass spectrometry based proteomics. However, changes in gene expression level may not directly be interpreted to alterations in proteins abundances. There are many ways how proteins, and especially enzymes, can be regulated to manage metabolic fluxes and ultimately, phenotypes, from protein translation, post-translational modifications and allosteric actors (metabolites). Thus, the read-out of cellular regulation must include metabolite analysis to explain a systemic view of responsive metabolism, called metabolomics. Here, various applications of metabolomics to study metabolic responses to genetic and/or environmental perturbation are presented as stands-alone research and also integrated analysis with mass-spectrometry based semi-quantitative proteomic approaches.
저자
Do Yup Lee [ Department of Advanced Fermentation Fusion Science and Technology, Kookmin University, Korea ]
Oliver Fiehn [ University of California Davis, Genome Center – Metabolomics, Davis 95616, California, U.S.A ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동