Earticle

초록

영어

An adequate knowledge on molecular mechanism of melanogenesis provides an opportunity to find the novel molecular targets for the new cosmetics discovery and development. These known targets are involved in other essential metabolic processes thus inhibition of their function affects the skin health. A nonpathogenic albinism caused by selective mutation or deletion of the OCA-2 gene have motivated us to target this gene and respective protein (P-protein) for new kind of cosmetics. The aim of the present work was to screen the molecule which specifically binds to this protein, resulting as inhibition of the melanin synthesis. Unfortunately, the structure of protein is not available, thus Dock based screening is pity hard. To resolve this we used a pattern search for amino acid sequence, based on homology analysis. The role of this protein have been cited more versatile than the regulating the tyrosine transport to melanosome. Thus, we have tried to generate a molecular library of a homologue to tyrosine and tyrosine-transporter inhibitor. Based on the dock-score five molecules have been subjected to ADME/TOX analysis. The molecules were predicted as non-carcinogenic by START program. Based on dock score a 20 molecule have been selected and 8 were found to be quite effective as anti melanogenic without having any toxicity. Among these compound, compound #1, #2, #3, #4, #8, #13, #16, #17 showed the significant antimelanogenic properties at a concentration of 20 mM. Further investigation in relation to mechanism of action is under process.

키워드

저자

• Vivek Kumar MORYA [ Dept. of Biotechnology, Inha University, Incheon, 402-751. ]
• Dung Hyang NGUYEN [ Dept. of Biotechnology, Inha University, Incheon, 402-751. ]
• Hyang-bok LEE [ Dept. of Biotechnology, Inha University, Incheon, 402-751. ]
• Eun-Ki KIM [ Dept. of Biotechnology, Inha University, Incheon, 402-751. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576