The photonic-based biosensing technologies have been utilized as one of the most useful tools for clinical diagnosis and bio-analysis owing to their analyzing performances with high sensitivity, wide dynamic range and simple mechanism of signal transducing. Among the diverse optical biosensors, the biosensors using evanescent field of optical wave are highly sensitive to the changes of the refractive index in the vicinity of sensor surfaces. Therefore, one can sensitively detect the biochemical substances bound to the surface without any labels in real time. Surface plasmon resonance (SPR), localized surface plasmon resonance (LSPR) [1,2] interferometric biosensors and optical waveguide sensors such as metal clad waveguide (MCW) [3-5] are categorized into this type of biosensor.The current presentation introduced highly sensitive detection of biomolecules using SPR and LSPR for the applications of bioassay and clinical diagnosis, including nanofabrication technologies realizing LSPR biosensor. In addition, we show that the MCW can be utilized for monitoring large biosubstances such as cells as well as for analyzing the biomolecular interaction.
키워드
optical biosensorrefractometrySPRLSPRwaveguide
저자
YONG BEOM SHIN [ Immunotheraphy Research Center, Korea Research Institute of Bioscience & Biotechonolgy. ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동