Earticle

초록

영어

Now a day much attention pay on planar Hall resistance (PHR) sensors due to its high signal-to-noise ratio, small offset voltage and very linear response at low field range compare to other magnetoresistive sensors [1]. In the past few years, multilayer sensor structures (bilayer, spinvalve or trilayer) have been investigated to progress the sensitivity of PHR sensor using cross-shaped sensor junction and the sensitivities of the PHR approximately 3, 7 and 12 uV/Oe respectively. Among these structures, the higher sensitivity has been obtained for trilayer due to small exchange bias field and small shunt current. For further improvement of the sensitivity, we have developed a new geometry (ring-shaped) of the sensor with Wheatstone bridge configuration over conventional cross-shaped. Both the output voltage and the sensitivity increases with the ring radius for a constant ring width. In addition, we have integrated multiple rings in a one ring junction of the sensor called multi-ring sensor, where the sensitivity of the sensor with 7 rings was found to be more than 600 uV/Oe. The interaction of biotin and streptavidin has been exploited using PHR sensor where this interaction is used in many protein and nucleic acid detection due to the streptavidin-biotin complex is the strongest known non-covalent interaction. We have performed the detection of streptavidin conjugated with magnetic label and biotin immobilization on the sensor surface modifying by APTES. We have succeeded to detect a 2.9 femto-molar (fM) concentration using PHR sensor. Figure: 3D-microscopic images of (a) cross-shaped, single-ring, multi-ring with 5 & 7 rings of PHR sensors, (b)
schematic of biotin-streptavidin conjugation with magnetic label for detection, (c) detection of femtomolar streptavidin.

저자

• B. Sinha [ Dept. of Materials Science, Chungnam National University, Daejeon, Korea ]
• J. I. Lim [ Dept. of Materials Science, Chungnam National University, Daejeon, Korea ]
• K. W. Kim [ Dept. of Materials Science, Chungnam National University, Daejeon, Korea ]
• CheolGi Kim [ Dept. of Materials Science, Chungnam National University, Daejeon, Korea ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576