Earticle

초록

영어

Recent developments in biomaterials for tissue engineering, novel cell culture techniques, and newly discovered chemicals as a replacement of the growth factors have opened new area toward the engineered technique of biomedical applications, for use in both research and clinical applications. Ideal bio-platform must be biocompatible that is to say, they should show both proper surface stability for the promotion of cell attachment and functions with drug delivery. However, plenty of challenges are still in progress, as the reason for the high compatibility of polymer film in cell culture environment and precisely controlled functional release of their drugs. To fulfill satisfactory of these requirements, attention has turned recently to not only introduce new materials but also developing nano-size controlled film structure of drug-delivery platformsassuchfilmscanenhancethespecificfunctionsincludingstimulicell-differentiation,- expansion,fightinginfectionandpromotin gwound- healing.Muchefforthasbeendevotedtocontrollingdrugreleaseviamanipulatingthedegradationordissolutionofth efilms. Layer-by-layer (LbL) self-assembly technic has been developed and used to prepared biocompatible multilayer films and polyelectrolyte capsulesfordrugdelivery.Certaindrugmolecules,suchasactiveproteins,cytokine,growthfactors,enzymes,nucl eicacids,andDNA,haveb eenimmobilizedintonano- sizedmultilayerfilms.TheadvantagesofLbLmultilayerfilmsasdrugdeliverysystemsincludethevariationofca ndidatematerials,alsodrugmoleculesitselfcanuseaseitherfunctionaldrugsorcomponentsofthefilm,andeasyto combinetoadditionalfunct ionsduetotheirevenlydistributedstructure.Furthermoresustaineddrugreleaseispossiblethroughcontrollingthefi lmphysical&chemicalp roperties,inadditionmultilayerfilmshavethepotentialtoprotectdrugmoleculesfromlosingtheirbiologicalfunctions ,andthefilmpreparati onprocessissimpleandcanbeautomated.Thedrugreleasebehaviorofpolyelectrolytemultilayerfilmsdependsont hepermeability,thedisas semblyorerosionofthemultilayerstructure,andotherexperimentalvariables. In this presentation, we prepared the cell friendly platform by take full advantages of LbL assembly with evenly distributed drug loading by nano-sized layer assembly. The platforms are prepared by various materials including not only synthetic-, natural-polymers but also functional materials such as growth factors, cytokines which are resulting different film degradation profiles. In addition, we also introduced the functional objects into multilayer film, such as block copolymer micelle as a drug container, nanotubes for enhanced mechanical strength. The structures including functional obejcts could be very useful in achieving additional functions for various cell studies. These results lay a cornerstone for future studies to achieve the multi-functional platforms including programmed loading/release of drugs for therapeutic purposes.

저자

• Jinkee Hong [ Chung-Ang University School of Chemical Engineering and Materials Science ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576