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Metabolic engineering of Escherichia coli for the production of 2-hydroxyacid containing polyesters
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- 발행기관
- 한국생물공학회 바로가기
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- 간행물
- 한국생물공학회 학술대회 바로가기
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- 통권
- 2013 춘계학술대회 (2013.04)바로가기
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- 페이지
- pp.105-105
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- 저자
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- 언어
- 영어(ENG)
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- URL
- https://www.earticle.net/Article/A197441
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
- 영어
- As the concerns about environmental problems, climate change and limited fossil resources increase, bio-based production of chemicals and polymers from renewable resources gains much attention as one of the promising solutions to deal with these problems. Polyhydroxyalkanoates (PHAs) are polyesters produced and accumulated in various microorganisms. PHAs are synthesized using monomers provided from metabolite precursors of diverse metabolic pathways and are accumulated as distinct granules inside the cells. On the other hand, most so called bio-based polymers including polybutylene succinate (PBS), polytrimethylene terephthalate (PTT), and polylactic acid (PLA) are synthesized by a chemical process using fermentation-derived monomers. PLA, an attractive biomass-derived thermoplastic, is currently synthesized by ring opening polymerization (ROP) of (L)-lactide that is made from fermentation-derived (L)-lactic acid. Recently, we have developed one-step fermentative synthesis process for the production of PLA and PLA copolymers from renewable resources employing recombinant bacteria equipped with PHA biosynthesis pathways coupled with a novel metabolic pathway. This could be accomplished by establishing a pathway for generating lactyl- CoA and engineering PHA synthase to accept lactyl-CoA as a monomer combined with systems metabolic engineering. In this presentation, we report recent advances in the production of lactate-containing homo- and co- polyesters, and furthermore 2-hydroxyacid containing polyesters in recombinant microorganisms. We will discuss challenges remaining to efficiently produce 2-hydroxyacid containing polyesters such as PLA, PLA copolymers and 2-hydroxybutyrate containing PHA and development of the metabolic engineering strategies to overcome these challenges.
키워드
PHA PLA 2-hydroxyacid polyester metabolic engineering저자
간행물 정보
발행기관
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- 발행기관명
- 한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
- 설립연도
- 1984
- 분야
- 공학>생물공학
- 소개
- 이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다 1. 생물공학 분야의 발전을 위한 연구 협력 2. 생물공학의 실용화를 촉진시키기 위한 산학 협동 3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최 4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간 5. 생물공학 발전을 위한 정책 건의 6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동
간행물
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- 간행물명
- 한국생물공학회 학술대회
- 간기
- 반년간
- 수록기간
- 1985~2013
- 십진분류
- KDC 476 DDC 576
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