Earticle

초록

영어

The anti-inflammatory effects of Sargassum fulvellum water extracts (SFWE) were investigated using lipopolysaccharide (LPS)-induced inflammatory response in this study. To examine the potential anti-inflammatory properties of SFWE, the NO, TNF-α, IL-6, IL-1β, and cell proliferation were measured. It was confirmed that the NO and TNF-α secretion were significantly suppressed when SFWE was added to LPS-stimulated RAW 264.7 cells. Moreover, the expression of IL-6 and IL-1β cytokines was suppressed by SFWE in a dose-dependent manner. Especially, IL-6 inhibition activities were over 50% at 1% of SFWE. The cytotoxicity of SFWE and the proliferation of macrophages was measured by MTT assay. As a result, there was no cytotoxicity in the macrophage proliferation treated with SFWE compared to the control. In conclusion, these results suggested that the SFWE may have significant effects on inflammatory factors and can be a potential anti-inflammatory therapeutic materials.

목차

Abstract
 1. 서론
 2. 재료 및 방법
  2.1. 실험 재료
  2.2. 추출
  2.3. 세포배양
  2.4. Nitric oxide 분비량 측정
  2.5. IL-6, TNF-α, IL-1β 분비량 측정
  2.6. 세포 독성 측정
  2.7. 통계 처리
 3. 결과 및 고찰
  3.1. RAW 264.7 세포의 NO 분비량
  3.2. RAW 264.7 세포의 IL-6 분비량
  3.3. RAW 264.7 세포의 TNF-α 분비량
  3.4. RAW 264.7 세포의 IL-1β 분비량
  3.5. 참모자반 물 추출물의 세포 독성
 4. 결론
 감사
 References

키워드

저자

• 정다현 [ Da-Hyun Jeong | 부경대학교 식품공학과/식품연구소 ]
• 김꽃봉우리 [ Koth-Bong-Woo-Ri Kim | 부경대학교 수산과학연구소 ]
• 강보경 [ Bo-Kyeong Kang | 부경대학교 식품공학과/식품연구소 ]
• 정슬아 [ Seul-A Jung | 부경대학교 식품공학과/식품연구소 ]
• 김현지 [ Hyun-Jee Kim | 부경대학교 식품공학과/식품연구소 ]
• 정희예 [ Hee-Ye Jeong | 부경대학교 식품공학과/식품연구소 ]
• 박시우 [ Si-Woo Bark | 부경대학교 식품공학과/식품연구소 ]
• 안동현 [ Dong-Hyun Ahn | 부경대학교 식품공학과/식품연구소 ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  KSBB Journal

• 간기

  격월간

• pISSN

  1225-7117

• 수록기간

  2009~2013

• 십진분류

  KDC 476 DDC 576