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Poster session C : Medicinal Mushroom/Fungi

Inhibitory effects of glycerol 3-phosphat acyltransferase (GPAT) activity and increase of glucose uptake by Ganoderma lucidum extracts

첫 페이지 보기
  • 발행기관
    한국버섯학회 바로가기
  • 간행물
    한국버섯학회지 바로가기
  • 통권
    제8권 제4호 (2010.12)바로가기
  • 페이지
    pp.201-201
  • 저자
    Eun-Suk Son, Hwi-Cheul Lee, Se-Ra Kim, Dae-eun Yoon, Woorijarang Han, Chang Soo Lee
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A194028

원문정보

초록

영어
Ganoderma lucidum has long been used as a potent medicinal plant. In addition, recent studies showed that G. lucidum is used to prevent or treat various human diseases such as allergy, hepatopathy, hypertension, cancer and diabetes. In this study showed that ethanol extract from G. lucidum have potential inhibitory effects of glycerol 3-phosphat acyltransferase (GPAT) activity and increase of glucose uptake on skeletal muscle cells. Inhibition of GPAT, which catalyze the first step in de novo TAG synthesis, has been proposed as one of the drug targets for insulin resistance and type-2 diabetes. G. lucidum extract inhibited GPAT activity. Bioassay-guided fractionation and isolation of bio-active substances from ethanol extracts of G. lucidum were carried out by using chromatographic techniques and in vitro GPAT enzyme assay. One of bioactive molecules, ergosterol peroxide, was isolated and identified by physical and spectral properties. In this study showed that ethanol extract from G. lucidum and ergosterol peroxide have potential anti- diabetes effects through the increase of glucose uptake. This was as sociated with increased activity AMP-activated protein kinase(AMPK). AMPK is another regulatory protein in the glucose uptake pathway and energy metabolism. The result was that the increase of glucose uptake by G. lucidum extract might be mediated by AMPK.

저자

  • Eun-Suk Son [ Department Applied Biochemistry, College of Biomedical & Health Science, Konkuk University, Chungju, 380-701, ]
  • Hwi-Cheul Lee [ National Institutes of Animal Science, Rural Development Administration, Suwon, 441-706, Republic of Korea ]
  • Se-Ra Kim [ Department Applied Biochemistry, College of Biomedical & Health Science, Konkuk University, Chungju, 380-701 ]
  • Dae-eun Yoon [ Department Applied Biochemistry, College of Biomedical & Health Science, Konkuk University, Chungju, 380-701 ]
  • Woorijarang Han [ Department Applied Biochemistry, College of Biomedical & Health Science, Konkuk University, Chungju, 380-701 ]
  • Chang Soo Lee [ Department Applied Biochemistry, College of Biomedical & Health Science, Konkuk University, Chungju, 380-701 ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국버섯학회 [The Korean Society of Mushroom Science]
  • 설립연도
    1997
  • 분야
    농수해양>농학
  • 소개
    우리나라의 버섯 연구와 관련 산업의 발전에 기여하고 버섯관련 연구자와 관련산업 종사자간의 학술정보 등의 교류를 목적으로 한다.

간행물

  • 간행물명
    한국버섯학회지 [Journal of MUSHROOMS]
  • 간기
    계간
  • pISSN
    1738-0294
  • eISSN
    2288-8853
  • 수록기간
    2003~2025
  • 등재여부
    KCI 등재
  • 십진분류
    KDC 525 DDC 635

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