Earticle

초록

영어

The effects of Ganoderma lucidum on glucose uptake was studied in L6 rat skeletal muscle cells. Glucose uptake in muscle cell was increased about 6-fold compared to control by mushroom extract treatment. This increasing effect to the glucose uptake was observed in muscle cells cultured with or without insulin. The levels of phosphor-acetyl CoA carboxylase were upregulated by G. lucidum extract treatment in insulinstimulated and basal culture conditions. However, G. lucidum extract did not affect protein kinaseB/Akt(Akt) level. Furthermore, the expression of phosphor-AMPactivated protein kinase(AMPK) was also up-regulated. AMPK is another regulatory protein in the glucose uptake pathway and energy metabolism. Thus, the treatment of G. lucidum extract in skeletal muscle cells increased the phosphorylation levels of AMPK and acetyl-CoA carboxylase, showing that the increase of glucose uptake by G. lucidum extract might be mediated via the activation of AMPK signaling pathway

저자

• Hye Ran Park [ Department of Applied Biochemistry, College of Biomedical & Health Science, Konkuk University ]
• Eun-Suk Son [ Department of Applied Biochemistry, College of Biomedical & Health Science, Konkuk University ]
• Se-Ra Kim [ Department of Applied Biochemistry, College of Biomedical & Health Science, Konkuk University ]
• Yeun-Song Kim [ Department of Applied Biochemistry, College of Biomedical & Health Science, Konkuk University ]
• Chang Soo Lee [ Department of Applied Biochemistry, College of Biomedical & Health Science, Konkuk University ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국버섯학회지 [Journal of MUSHROOMS]

• 간기

  계간

• pISSN

  1738-0294

• eISSN

  2288-8853

• 수록기간

  2003~2025

• 등재여부

  KCI 등재

• 십진분류

  KDC 525 DDC 635