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2006년도 춘계 한국버섯학회 발표 논문 초록

Bcl-2 Overexpression Attenuates Agaricus blazei Murill-Induced Apoptosis in U937 Cells by Inhibition of Caspase-3 Activit

첫 페이지 보기
  • 발행기관
    한국버섯학회 바로가기
  • 간행물
    한국버섯학회지 바로가기
  • 통권
    제4권 제2호 (2006.06)바로가기
  • 페이지
    pp.74-74
  • 저자
    Cheng-Yun Jin, Gi-Young Kim, Jae-Yun Lee, Mun-Ok Kim, Jin-Young Park, Dong-Oh Moon, Yung-Hyun Choi, Jae-Dong Lee
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A193340

원문정보

초록

영어
Agaricus blazeiMurill is an edible mushroom distributed in Brazil and presently cultivated in other areas, including Korea, Japan, and China. Its chemical components, including steroids and lectin and various polysaccharides have been widely studied. For this, we used U937/vector and U937/Bcl-2 cells, which were generated by transfection of the cDNA of the Bcl-2 gene. As compared with U937/vector, U937/Bcl-2 cells exhibited a 4-fold greater expression of Bcl-2. Treatment with 0.5 or 4 mg/ml A. blazei Murill for 24 h produced morphological features of apoptosis in U937/vector cells, respectively. This was associated with caspase-3 activation and PARP degradation. In contrast, A. blazei Murill-induced caspase-3 activation and PARP degradation and apoptosis were significantly inhibited by z-DEVD-fmk in U937 cells. Bcl-2 overexpressing cells exhibited sustained caspase-3 activation and expression levels of the Bcl-2 proteins during A. blazei Murill-induced apoptosis. In addition, these findings indicate that Bcl-2 inhibits A. blazei Murill-induced apoptosis by a mechanism that interferes with Bcl-2 degradation and activity of caspase-3 that is involved in the execution of apoptosi.

저자

  • Cheng-Yun Jin [ Department of microbiology, College of Natural Sciences, Pusan National University ]
  • Gi-Young Kim [ Faculty of Applied Marine Science, Cheju National University ]
  • Jae-Yun Lee [ Department of microbiology, College of Natural Sciences, Pusan National University ]
  • Mun-Ok Kim [ Department of microbiology, College of Natural Sciences, Pusan National University ]
  • Jin-Young Park [ Department of microbiology, College of Natural Sciences, Pusan National University ]
  • Dong-Oh Moon [ Faculty of Applied Marine Science, Cheju National University ]
  • Yung-Hyun Choi [ Department of Biochemistry, Dongeui University College of Oriental Medicine ]
  • Jae-Dong Lee [ Department of microbiology, College of Natural Sciences, Pusan National University ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국버섯학회 [The Korean Society of Mushroom Science]
  • 설립연도
    1997
  • 분야
    농수해양>농학
  • 소개
    우리나라의 버섯 연구와 관련 산업의 발전에 기여하고 버섯관련 연구자와 관련산업 종사자간의 학술정보 등의 교류를 목적으로 한다.

간행물

  • 간행물명
    한국버섯학회지 [Journal of MUSHROOMS]
  • 간기
    계간
  • pISSN
    1738-0294
  • eISSN
    2288-8853
  • 수록기간
    2003~2025
  • 등재여부
    KCI 등재
  • 십진분류
    KDC 525 DDC 635

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