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The Functional Study of O-GlcNAc Modification Related with EMT under Hypoglycemic Condition
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- 발행기관
- 한국당과학회 바로가기
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- 간행물
- 한국당과학회 학술대회 바로가기
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- 통권
- ACGG 2012 Conference (2012.10)바로가기
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- 페이지
- pp.105-105
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- 저자
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- 언어
- 영어(ENG)
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- URL
- https://www.earticle.net/Article/A192936
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
- 영어
- Most cancer cells produce energy by glycolysis followed by fermentation in the cytosol, even though they exist in the presence of oxygen. It means that glucose is probably important to cancer growth and survival more than oxygen. But the research about cancer metastasis has been limited to hypoxia condition until now. Interestingly it was reported that overall O-GlcNAc modification on protein was significantly increased under hypoglycemic condition.
O-GlcNAcylation is one of the post-translational protein modification and it appears to be involved in many different cellular activitiesregulating in transcription, translation, protein degradation, protein localization and protein-protein interaction. And O-GlcNAcylation on snail1, p120 and beta-catenin induces the decrease of E-cadherin on plasma membrane, so it was thought that O-GlcNAcylation is also related with EMT (epithelial mesenchymal transition).
In our study, we want to examine whether hypoglycemic condition can induce cancer metastasis and it is related to increased O-GlcNAc modification induced by hypoglycemic condition or not. So we focused on EMT to visualize cancer metastasis. We found that vimentin which is mesenchymal cell marker was increased and it was O-GlcNAcylated under hypoglycemic condition in cancer cell. Also, we confirmed that epithelial cell markers were also decreased under hypoglycemic condition. These findings tell us that hypoglycemic condition can be closely connected with cancer metastasis via O-GlcNAclation. So we suggest possibilities that hypoglycemic condition induced EMT in cancer cell and it related with increased O-GlcNAc modification.
저자
간행물 정보
발행기관
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- 발행기관명
- 한국당과학회 [Korean Society for Glycoscience]
- 설립연도
- 2006
- 분야
- 의약학>약학
- 소개
- 본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.
간행물
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- 간행물명
- 한국당과학회 학술대회
- 간기
- 연간
- 수록기간
- 2006~2022
- 십진분류
- KDC 517 DDC 614
이 권호 내 다른 논문 / 한국당과학회 학술대회 ACGG 2012 Conference
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