We present here a high-throughput strategy to discover serological biomarkers for early-detection of hepatocellular carcinoma (HCC). Our strategy is also applicable to assess the progressed liver fibrosis that is associated with virus hepatitis. The glycan structure on glycoproteins derived from cancerous cells is known to be different from that derived from normal cells, specifically, the increased aberrant glycosylation appears in patient serum with virus hepatitis along with either or both the initiation and progression. Based on the above perceptions, in order to identify glycoproteins carrying aberrant glycosylation in serum of liver disease patients, we analyzed lectin-captured glycopeptides by the IGOT method. Many glycoproteins carrying altered glycans were successfully identified. The increased amount of these glycoproteins was clinically relevant to the progression of the liver diseases. We are now selecting appropriate molecules depending on the feasibility to detect an abnormality in the liver, such as the occurrence of liver cell neoplasm.
저자
Hiroyuki Kaji [ Research Centre for Medical Glycomscience, National Institute of Advanced Industrial Science And Technology, Tsukuba, Umezono, 1-1-1, Japan ]
Akira Togayachi [ Research Centre for Medical Glycomscience, National Institute of Advanced Industrial Science And Technology, Tsukuba, Umezono, 1-1-1, Japan ]
Makoto Ochou [ Research Centre for Medical Glycomscience, National Institute of Advanced Industrial Science And Technology, Tsukuba, Umezono, 1-1-1, Japan ]
Maki Sogabe [ Research Centre for Medical Glycomscience, National Institute of Advanced Industrial Science And Technology, Tsukuba, Umezono, 1-1-1, Japan ]
Takashi Okura [ Research Centre for Medical Glycomscience, National Institute of Advanced Industrial Science And Technology, Tsukuba, Umezono, 1-1-1, Japan ]
Hirofumi Nozaki [ Research Centre for Medical Glycomscience, National Institute of Advanced Industrial Science And Technology, Tsukuba, Umezono, 1-1-1, Japan ]
Takashi Angata [ Research Centre for Medical Glycomscience, National Institute of Advanced Industrial Science And Technology, Tsukuba, Umezono, 1-1-1, Japan ]
Yasunori Chiba [ Research Centre for Medical Glycomscience, National Institute of Advanced Industrial Science And Technology, Tsukuba, Umezono, 1-1-1, Japan ]
Hidenori Ozaki [ Research Centre for Medical Glycomscience, National Institute of Advanced Industrial Science And Technology, Tsukuba, Umezono, 1-1-1, Japan ]
Atsushi Kuno [ Research Centre for Medical Glycomscience, National Institute of Advanced Industrial Science And Technology, Tsukuba, Umezono, 1-1-1, Japan ]
Yasuhito Tanaka [ Department of Virology and Liver, Nagoya City University Medical School, Nagoya, Mozuho, Kawasumi, 1, Japan ]
Yuzuru Ikehara [ Research Centre for Medical Glycomscience, National Institute of Advanced Industrial Science And Technology, Tsukuba, Umezono, 1-1-1, Japan ]
Masashi Mizokami [ Research Centre of Japan.Hepatitis and Immunology, Kohnodai Hospital, International Medical Centre, Ichikawa, Kohnodai, 1-7-1, Japan ]
Hisashi Narimatsu [ Research Centre for Medical Glycomscience, National Institute of Advanced Industrial Science And Technology, Tsukuba, Umezono, 1-1-1, Japan ]
본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.
