Bernadeth F. Ticar, Zuliyati Rohmah, Si-Hyang Park, Yeung Joon Choi, Seok-Jeong Kang, Byeong-dae Choi
언어
영어(ENG)
URL
https://www.earticle.net/Article/A192928
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원문정보
초록
영어
The polysaccharides extracted from Liparis tesellatus eggs (LEP) and Pronase-digested LEP (LEP-PD) were tested for their anti-inflammatory, anti-cancer, and cytotoxic activities. The anti-inflammatory activities were determined using NO production by macrophage RAW 264.7 cell lines induced by lipopolysaccharide (LPS). Results showed that LEP-PD has an activity on all concentrations (0.01, 0.1, 1.0, 10.0, 100.0, and 200.0 ug/ml), whereas, no activity on all concentrations prepared for LEP. The anti-cancer activities of LEP and LEP-PD were evaluated using Human colon adenocarcinoma (HT-29) and Human stomach adenocarcinoma (AGS) cell lines. Results showed that both the LEP and LEP-PD have anti-carcinogenic effects on these specific cell lines. For the cytotoxic effects of LEP and LEP-PD, RAW 264.7 cell line was also used treated with the polysaccharides. The results showed that LEP and LEP-PD are non-toxic to the cells. From these data obtained, polysaccharides from Liparis tesellatus eggs can be used in the field of medicine upon further purification and elucidation of the structures of the glycans responsible for these promising activities.
저자
Bernadeth F. Ticar [ Gyeongsang National University/ Institute of Marine Industry, South Korea ]
Zuliyati Rohmah [ Gyeongsang National University/ Institute of Marine Industry, South Korea ]
Si-Hyang Park [ Gyeongsang National University/ Institute of Marine Industry, South Korea ]
Yeung Joon Choi [ Gyeongsang National University/ Institute of Marine Industry, South Korea ]
Seok-Jeong Kang [ Gyeongsang National University/ Institute of Marine Industry, South Korea ]
Byeong-dae Choi [ Gyeongsang National University/ Institute of Marine Industry, South Korea ]
본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.